Abstract Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …

Gaussian accelerated molecular dynamics (GaMD) is a robust computational method for
simultaneous unconstrained enhanced sampling and free energy calculations of …

Adenosine receptors (ARs) function in the body's response to conditions of pathology and
stress associated with a functional imbalance, such as in the supply and demand of …

Adenosine is involved in a range of physiological and pathological effects through
membrane-bound receptors linked to G proteins. There are four subtypes of adenosine …

Medicinal chemical approaches have been applied to all four of the adenosine receptor
(AR) subtypes (A1, A2A, A2B, and A3) to create selective agonists and antagonists for each …

Adenosine receptor agonists have potent antinociceptive effects in diverse preclinical
models of chronic pain. By contrast, the efficacy of adenosine and adenosine receptor …

Adenosine exerts an important role in the modulation of central nervous system (CNS)
activity. Through the interaction with four G-protein coupled receptor (GPCR) subtypes …

The purinergic signalling system is one of the most ancient and arguably the most
widespread intercellular signalling system in living tissues. In this review we present a …

The pancreas is an organ with a central role in nutrient breakdown, nutrient sensing and
release of hormones regulating whole body nutrient homeostasis. In diabetes mellitus, the …

Adipose tissue is the only tissue capable of hydrolyzing its stores of triacylglycerol (TAG) and
of mobilizing fatty acids and glycerol in the bloodstream so that they can be used by other …