Amino acid modification plays an important role across several fields, including synthetic
organic chemistry, materials science, targeted drug delivery and the probing of biological …

Biomolecule-polymer conjugates are constructs that take advantage of the functional or
otherwise beneficial traits inherent to biomolecules and combine them with synthetic …

The amidated peptides are an important class of biologically active compounds due to their
unique biological properties and wide applications as potential peptide drugs and …

Here we report a nonenzymatic glycosylation reaction that builds axial S-glycosidic bonds
under biorelevant conditions. This strategy is enabled by the design and use of allyl glycosyl …

The chemistry of heterocyclic compounds has traditionally been and remains a bright area of
chemical science in Russia. This is due to the fact that many heterocycles find the widest …

Chromones represent a privileged scaffold in medicinal chemistry and are an omnipresent
structural motif in natural products. Chemically encoded non-natural peptidomimetics feature …

Bioorthogonal late-stage diversification of amino acids and peptides bears enormous
potential for drug discovery and molecular imaging. Despite major accomplishments, these …

Peptide macrocyclization has traditionally relied on lactam, lactone and disulfide bond-
forming reactions that aim at introducing conformational constraints into small peptide …

The site-selective modification of peptide backbones allows an outstanding fine-tuning of
peptide conformation, folding ability, and physico-chemical and biological properties …

Development of bioconjugation strategies to efficiently modify biomolecules is of key
importance for fundamental and translational scientific studies. Cysteine S-arylation is an …