The high metabolic demand of cancer cells leads to an accumulation of H+ ions in the
tumour microenvironment. The disorganized tumour vasculature prevents an efficient wash …

Six genetic families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were described to
date. Inhibition of CAs has pharmacologic applications in the field of antiglaucoma …

Abstract The RCSB Protein Data Bank (RCSB PDB, http://www. rcsb. org) provides access to
3D structures of biological macromolecules and is one of the leading resources in biology …

Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …

Acute inflammation or resolved inflammation is an adaptive host defense mechanism and is
self-limiting, which returns the body to a state of homeostasis. However, unresolved …

For the past decade, the number of molecular targets for approved drugs has been debated.
Here, we reconcile apparently contradictory previous reports into a comprehensive survey …

Inhibition of the metalloenzyme carbonic anhydrase (CA; EC 4.2. 1.1) has pharmacologic
applications in the field of anti-glaucoma, anti-convulsant and anti-cancer agents. But …

For much of the past century, drug discovery relied largely on the use of animal models of
disease as the first-line screens for testing the compounds produced by medicinal chemists …

The tumor microenvironment includes a complicated network of physiological gradients
contributing to plasticity of tumor cells and heterogeneity of tumor tissue. Hypoxia is a key …

The endoplasmic reticulum (ER) is a multifunctional organelle required for lipid biosynthesis,
calcium storage, and protein folding and processing. A number of physiological and …