A brief introduction to chemical reaction optimization

CJ Taylor, A Pomberger, KC Felton, R Grainger… - Chemical …, 2023 - ACS Publications
From the start of a synthetic chemist's training, experiments are conducted based on recipes
from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist …

Technological innovations in photochemistry for organic synthesis: flow chemistry, high-throughput experimentation, scale-up, and photoelectrochemistry

L Buglioni, F Raymenants, A Slattery… - Chemical …, 2021 - ACS Publications
Photoinduced chemical transformations have received in recent years a tremendous amount
of attention, providing a plethora of opportunities to synthetic organic chemists. However …

Photons or electrons? A critical comparison of electrochemistry and photoredox catalysis for organic synthesis

NES Tay, D Lehnherr, T Rovis - Chemical reviews, 2021 - ACS Publications
Redox processes are at the heart of synthetic methods that rely on either electrochemistry or
photoredox catalysis, but how do electrochemistry and photoredox catalysis compare? Both …

Photocatalysis in the life science industry

L Candish, KD Collins, GC Cook, JJ Douglas… - Chemical …, 2021 - ACS Publications
In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …

Strategies to generate nitrogen-centered radicals that may rely on photoredox catalysis: development in reaction methodology and applications in organic synthesis

K Kwon, RT Simons, M Nandakumar… - Chemical …, 2021 - ACS Publications
For more than 70 years, nitrogen-centered radicals have been recognized as potent
synthetic intermediates. This review is a survey designed for use by chemists engaged in …

Photochemical and electrochemical applications of proton-coupled electron transfer in organic synthesis

PRD Murray, JH Cox, ND Chiappini, CB Roos… - Chemical …, 2021 - ACS Publications
We present here a review of the photochemical and electrochemical applications of multi-
site proton-coupled electron transfer (MS-PCET) in organic synthesis. MS-PCETs are redox …

Organic thermally activated delayed fluorescence (TADF) compounds used in photocatalysis

MA Bryden, E Zysman-Colman - Chemical Society Reviews, 2021 - pubs.rsc.org
Organic compounds that show Thermally Activated Delayed Fluorescence (TADF) have
become wildly popular as next-generation emitters in organic light emitting diodes (OLEDs) …

A general and modular approach to BCP alkylamines via multicomponent difunctionalization of [1.1. 1] propellane

W Huang, Y Zheng, S Keess… - Journal of the American …, 2023 - ACS Publications
Over the past decade, bicyclo [1.1. 1] pentane (BCP) motifs have come to the fore as
valuable pharmaceutical bioisosteres of para-disubstituted benzenes. However, the limited …

Catalytic asymmetric reductive azaarylation of olefins via enantioselective radical coupling

Y Li, C Han, Y Wang, X Huang, X Zhao… - Journal of the …, 2022 - ACS Publications
Visible-light-driven photocatalytic reductive azaarylation has been widely used to construct
the important imine-containing azaarene derivatives. In addition to the direct use of various …

Synthesis of azetidines via visible-light-mediated intermolecular [2+ 2] photocycloadditions

MR Becker, ER Wearing, CS Schindler - Nature Chemistry, 2020 - nature.com
Abstract Intermolecular [2+ 2] photocycloadditions represent a powerful method for the
synthesis of highly strained, four-membered rings. Although this approach is commonly …