Uniquely among human senses, hearing is not simply a passive response to stimulation.
Our auditory system is instead enhanced by an active process in cochlear hair cells that …

Sound pressure fluctuations striking the ear are conveyed to the cochlea, where they vibrate
the basilar membrane on which sit hair cells, the mechanoreceptors of the inner ear …

Sound is encoded within the auditory portion of the inner ear, the cochlea, after propagating
down its length as a traveling wave. For over half a century, vibratory measurements to study …

Cisplatin is widely used for the treatment of a number of solid malignant tumors. However,
ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for …

Most sounds of interest consist of complex, time-dependent admixtures of tones of diverse
frequencies and variable amplitudes. To detect and process these signals, the ear employs …

The exquisite sensitivity and frequency discrimination of mammalian hearing underlie the
ability to understand complex speech in noise. This requires force generation by cochlear …

Noise-induced excitotoxicity is thought to depend on glutamate. However, the excitotoxic
mechanisms are unknown, and the necessity of glutamate for synapse loss or regeneration …

The outstanding acuity of the mammalian ear relies on cochlear amplification, an active
mechanism based on the electromotility (eM) of outer hair cells. eM is a piezoelectric …

It is commonly believed that the exceptional sensitivity of mammalian hearing depends on
outer hair cells which generate forces for amplifying sound-induced basilar membrane …

The operation of the mammalian cochlea relies on a mechanical traveling wave that is
actively boosted by electromechanical forces in sensory outer hair cells (OHCs). This active …