Mechanisms of SARS-CoV-2 transmission and pathogenesis
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) marks
the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 …
the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 …
Subunit vaccines against emerging pathogenic human coronaviruses
Seven coronaviruses (CoVs) have been isolated from humans so far. Among them, three
emerging pathogenic CoVs, including severe acute respiratory syndrome coronavirus …
emerging pathogenic CoVs, including severe acute respiratory syndrome coronavirus …
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
The papain-like protease PLpro is an essential coronavirus enzyme that is required for
processing viral polyproteins to generate a functional replicase complex and enable viral …
processing viral polyproteins to generate a functional replicase complex and enable viral …
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
T Klemm, G Ebert, DJ Calleja, CC Allison… - The EMBO …, 2020 - embopress.org
The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …
[HTML][HTML] Innate immune evasion by human respiratory RNA viruses
M Kikkert - Journal of innate immunity, 2020 - karger.com
The impact of respiratory virus infections on the health of children and adults can be very
significant. Yet, in contrast to most other childhood infections as well as other viral and …
significant. Yet, in contrast to most other childhood infections as well as other viral and …
Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies
YW Zhou, Y Xie, LS Tang, D Pu, YJ Zhu… - Signal transduction and …, 2021 - nature.com
Owing to the limitations of the present efforts on drug discovery against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …
Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein
J Lei, Y Kusov, R Hilgenfeld - Antiviral research, 2018 - Elsevier
The multi-domain non-structural protein 3 (Nsp3) is the largest protein encoded by the
coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an …
coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an …
Drug development and medicinal chemistry efforts toward SARS‐coronavirus and Covid‐19 therapeutics
AK Ghosh, M Brindisi, D Shahabi… - …, 2020 - Wiley Online Library
The COVID‐19 pandemic caused by SARS‐CoV‐2 infection is spreading at an alarming
rate and has created an unprecedented health emergency around the globe. There is no …
rate and has created an unprecedented health emergency around the globe. There is no …
Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease
BT Freitas, IA Durie, J Murray, JE Longo… - ACS infectious …, 2020 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for
COVID-19, is a novel human betacoronavirus that is rapidly spreading worldwide. The …
COVID-19, is a novel human betacoronavirus that is rapidly spreading worldwide. The …
Deubiquitylating enzymes and drug discovery: emerging opportunities
JA Harrigan, X Jacq, NM Martin… - Nature reviews Drug …, 2018 - nature.com
More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitin–
proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors …
proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors …