Enhancers are cis-regulatory elements in the genome that cooperate with promoters to
control target gene transcription. Unlike promoters, enhancers are not necessarily adjacent …

Clinical development of bromodomain and extra‐terminal (BET) protein inhibitors differs
from the traditional course of drug development. These drugs are simultaneously being …

A small set of core transcription factors (TFs) dominates control of the gene expression
program in embryonic stem cells and other well-studied cellular models. These core TFs …

Single-cell transcriptomics promise to revolutionize our understanding of the vasculature.
Emerging computational methods applied to high-dimensional single-cell data allow …

Atherosclerosis is a vascular pathology characterized by inflammation and plaque build-up
within arterial vessel walls. Vessel occlusion, often occurring after plaque rupture, can result …

During intestinal organogenesis, equipotent epithelial progenitors mature into
phenotypically distinct stem cells that are responsible for lifelong maintenance of the tissue …

Postprandial IL-1β surges are predominant in the white adipose tissue (WAT), but its
consequences are unknown. Here, we investigate the role of IL-1β in WAT energy storage …

The molecular basis of signal-dependent transcriptional activation has been extensively
studied in macrophage polarization, but our understanding remains limited regarding the …

Rapid perturbation of protein function permits the ability to define primary molecular
responses while avoiding downstream cumulative effects of protein dysregulation. The auxin …

Objective NFκB is the key modulator in inflammatory disorders. However, the key regulators
that activate, fine-tune or shut off NFκB activity in inflammatory conditions are poorly …