Germline alterations in many genes coding for proteins regulating DNA repair and DNA
damage response (DDR) to DNA double-strand breaks (DDSB) have been recognized as …

The serine/threonine kinase CHK2 is a key component of the DNA damage response. In
human cells, following genotoxic stress, CHK2 is activated and phosphorylates> 20 proteins …

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …

Purpose Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition
characterized by somatic mutations in the blood of otherwise healthy adults. We …

DNA damage initiates a series of p53 pulses. Although much is known about the interactions
surrounding p53, little is known about which interactions contribute to p53's dynamical …

The tumor suppressor p53 is a transcription factor that responds to cellular stresses by
initiating cell cycle arrest or apoptosis. One transcriptional target of p53 is Mdm2, an E3 …

In the past decade, CHK2 has emerged as an important multifunctional player in the DNA-
damage response signalling pathway. Parallel studies of the human CHEK2 gene have also …

The cellular DNA damage response (DDR) is activated by many types of DNA lesions. Upon
recognition of DNA damage by sensor proteins, an intricate signal transduction network is …

Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to
surgically resect. To determine the genetic and epigenetic landscape of these tumors, we …

The W ild-type p53-i nduced p hosphatase 1, Wip1 (or PPM1D), is unusual in that it is a
serine/threonine phosphatase with oncogenic activity. A member of the type 2C …