DNA as a universal chemical substrate for computing and data storage

S Yang, BWA Bögels, F Wang, C Xu, H Dou… - Nature Reviews …, 2024 - nature.com
DNA computing and DNA data storage are emerging fields that are unlocking new
possibilities in information technology and diagnostics. These approaches use DNA …

Engineering DNA-based cytoskeletons for synthetic cells

K Jahnke, K Göpfrich - Interface Focus, 2023 - royalsocietypublishing.org
The development and bottom-up assembly of synthetic cells with a functional cytoskeleton
sets a major milestone to understand cell mechanics and to develop man-made machines …

Triggered contraction of self-assembled micron-scale DNA nanotube rings

M Illig, K Jahnke, LP Weise, M Scheffold… - Nature …, 2024 - nature.com
Contractile rings are formed from cytoskeletal filaments during cell division. Ring formation is
induced by specific crosslinkers, while contraction is typically associated with motor protein …

Lipid vesicle-based molecular robots

Z Peng, S Iwabuchi, K Izumi, S Takiguchi, M Yamaji… - Lab on a Chip, 2024 - pubs.rsc.org
A molecular robot, which is a system comprised of one or more molecular machines and
computers, can execute sophisticated tasks in many fields that span from nanomedicine to …

Light‐Activated Assembly of DNA Origami into Dissipative Fibrils

WR Berg, JF Berengut, C Bai, L Wimberger… - Angewandte …, 2023 - Wiley Online Library
Hierarchical DNA nanostructures offer programmable functions at scale, but making these
structures dynamic, while keeping individual components intact, is challenging. Here we …

Synthetic Cells Revisited: Artificial Cells Construction Using Polymeric Building Blocks

V Maffeis, L Heuberger, A Nikoletić… - Advanced …, 2024 - Wiley Online Library
The exponential growth of research on artificial cells and organelles underscores their
potential as tools to advance the understanding of fundamental biological processes. The …

Polysaccharide functionalization reduces lipid vesicle stiffness

K Jahnke, M Pavlovic, W Xu, A Chen… - Proceedings of the …, 2024 - National Acad Sciences
The biophysical properties of lipid vesicles are important for their stability and integrity, key
parameters that control the performance when these vesicles are used for drug delivery. The …

DNA-empowered synthetic cells as minimalistic life forms

A Samanta, L Baranda Pellejero, M Masukawa… - Nature Reviews …, 2024 - nature.com
Cells, the fundamental units of life, orchestrate intricate functions—motility, adaptation,
replication, communication, and self-organization within tissues. Originating from …

Precise construction of DNA origami‐based materials for functional regulation on biological interface

Y Wu, X Wu, R Tian, Y Wang, B Ding… - Smart …, 2024 - Wiley Online Library
Precise design and control of molecular self‐assembly as living creatures are exciting ideas
in the field of nanotechnology. Characterized with predesigned geometries and accurate …

Genetic encoding and expression of RNA origami cytoskeletons in synthetic cells

MP Tran, T Chakraborty, E Poppleton, L Monari… - bioRxiv, 2024 - biorxiv.org
The central dogma at the core of molecular biology states that information flows from DNA to
RNA and then to protein. Our research seeks to introduce a conceptually novel approach …