Alcohol-associated hepatitis

R Bataller, JP Arab, VH Shah - New England Journal of Medicine, 2022 - Mass Medical Soc
Alcohol-Associated Hepatitis | New England Journal of Medicine Skip to main content The New
England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …

Recent advances in understanding of pathogenesis of alcohol-associated liver disease

X Wu, X Fan, T Miyata, A Kim… - Annual Review of …, 2023 - annualreviews.org
Alcohol-associated liver disease (ALD) is one of the major diseases arising from chronic
alcohol consumption and is one of the most common causes of liver-related morbidity and …

Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice

RN Helsley, T Miyata, A Kadam, V Varadharajan… - Elife, 2022 - elifesciences.org
There is mounting evidence that microbes residing in the human intestine contribute to
diverse alcohol-associated liver diseases (ALD) including the most deadly form known as …

Research methodologies to address clinical unmet needs and challenges in alcohol‐associated liver disease

AK Singal, P Kwo, A Kwong, S Liangpunsakul… - …, 2022 - Wiley Online Library
Alcohol‐associated liver disease (ALD) is emerging worldwide as the leading cause of liver‐
related morbidity, mortality, and indication for liver transplantation. The ALD Special Interest …

[HTML][HTML] In severe alcoholic hepatitis, serum keratin-18 fragments are diagnostic, prognostic, and theragnostic biomarkers

SR Atkinson, JI Grove, S Liebig, S Astbury… - Official journal of the …, 2020 - journals.lww.com
METHODS: Total (K18-M65) and caspase-cleaved K18 (K18-M30) were quantified in
pretreatment sera from 824 patients enrolled in the Steroids or Pentoxifylline for Alcoholic …

Management of alcoholic hepatitis: A clinical perspective

P Kasper, S Lang, HM Steffen, M Demir - Liver International, 2023 - Wiley Online Library
Alcohol‐associated liver disease is the primary cause of liver‐related mortality worldwide
and one of the most common indications for liver transplantation. Alcoholic hepatitis …

The application of cytokeratin-18 as a biomarker for drug-induced liver injury

S Korver, J Bowen, K Pearson, RJ Gonzalez… - Archives of …, 2021 - Springer
Drug-induced liver injury (DILI) is a frequent and dangerous adverse effect faced during
preclinical and clinical drug therapy. DILI is a leading cause of candidate drug attrition …

[HTML][HTML] Differential role of MLKL in alcohol-associated and non–alcohol-associated fatty liver diseases in mice and humans

T Miyata, X Wu, X Fan, E Huang, C Sanz-Garcia… - JCI insight, 2021 - ncbi.nlm.nih.gov
Hepatocellular death contributes to progression of alcohol–associated (ALD-associated)
and non–alcohol-associated (NAFL/NASH) liver diseases. However, receptor-interaction …

Liver alterations are not improved by inulin supplementation in alcohol use disorder patients during alcohol withdrawal: a pilot randomized, double-blind, placebo …

C Amadieu, L Maccioni, S Leclercq, AM Neyrinck… - …, 2022 - thelancet.com
Background Emerging evidence highlights that targeting the gut microbiota could be an
interesting approach to improve alcohol liver disease due to its important plasticity. This …

Blood BTEXS and heavy metal levels are associated with liver injury and systemic inflammation in Gulf states residents

EJ Werder, JI Beier, DP Sandler, KC Falkner… - Food and Chemical …, 2020 - Elsevier
Introduction Exposures to volatile organic compounds and metals have previously been
associated with liver diseases including steatohepatitis, although more data are needed …