Protein phosphorylation is a crucial regulator of protein and cellular function, yet, despite
identifying an enormous number of phosphorylation sites, the role of most is still unclear …

The ability to manipulate the chemical composition of proteins and peptides has been
central to the development of improved polypeptide-based therapeutics and has enabled …

Inteins are protein segments that are capable of enabling the ligation of flanking extein into a
new protein, a process known as protein splicing. Since its discovery, inteins have become …

Synthetic Biology is a rapidly growing interdisciplinary field that is primarily built upon
foundational advances in molecular biology combined with engineering design principles …

Protein methylation is a key post-translational modification whose effects on gene
expression have been intensively studied over the last two decades. Recently, renewed …

Amyloid proteins are widely studied, both for their unusual biophysical properties and their
association with disorders such as Alzheimer's and Parkinson's disease. Fluorescence …

The voltage-gated sodium channel Nav1. 5 initiates the cardiac action potential. Alterations
of its activation and inactivation properties due to mutations can cause severe, life …

Ion channels play central roles in biology and human health by catalyzing the
transmembrane flow of electrical charge. These proteins are ideal targets for genetic code …

Split intein-mediated protein trans-splicing (PTS) is widely applied in chemical biology and
biotechnology to carry out traceless and specific protein ligation. However, the external …

Biological properties of protein molecules depend on their interaction with other molecules,
and enzymes are no exception. Enzyme activities are controlled by their interaction with …