Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

Like all retroviruses, the human immunodeficiency virus selectively packages two copies of
its unspliced RNA genome, both of which are utilized for strand-transfer-mediated …

This review focuses on recent advances in instrumentation, techniques, and applications of
the highest resolution mass analyzers (multipass time of flight (TOF), orbitrap, and Fourier …

RNA is arguably the most versatile biological macromolecule because of its ability both to
encode and to manipulate genetic information. The diverse roles of RNA depend on its …

The 5′-leader of the HIV-1 genome regulates multiple functions during viral replication via
mechanisms that have yet to be established. We developed a nuclear magnetic resonance …

Tertiary structure prediction is important for understanding structure–function relationships
for RNAs whose structures are unknown and for characterizing RNA states recalcitrant to …

The most conserved region of the HIV type 1 (HIV-1) genome, the∼ 335-nt 5′ UTR, is
characterized by functional stem loop domains responsible for regulating the viral life cycle …

RNA molecules are master regulators of cells. They are involved in a variety of molecular
processes: they transmit genetic information, sense cellular signals and communicate …

In this report, we explored the benefits of cyclic ion mobility (cIM) mass spectrometry in the
analysis of isomeric post-transcriptional modifications of RNA. Standard methyl-cytidine …

This review discusses various mass spectrometry (MS)‐based approaches for exploring
structural aspects of proteins in solution. Electrospray ionization (ESI)–MS, in particular, has …