Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …

Higher-order chromatin structure is important for the regulation of genes by distal regulatory
sequences,. Structural variants (SVs) that alter three-dimensional (3D) genome organization …

The cohesin complex has an essential role in maintaining genome organization. However,
its role in gene regulation remains largely unresolved. Here we report that the cohesin …

Simple Summary Here, we review the literature on Activating Enhancer-Binding Protein 4
(AP4)/transcription factor AP4 (TFAP4) function and regulation and its role in cancer …

Background The dynamic epigenome and proteins specialized in the interpretation of
epigenetic marks critically contribute to leukemic pathogenesis but also offer alternative …

Genome-wide association studies (GWASs) have reproducibly associated variants within
intergenic regions of 1p36. 12 locus with osteoporosis, but the functional roles underlying …

Large-scale sequencing studies discovered substantial genetic variants occurring in
enhancers which regulate genes via long range chromatin interactions. Importantly, such …

Genomic instability pathways in colorectal cancer (CRC) have been extensively studied, but
the role of retrotransposition in colorectal carcinogenesis remains poorly understood …

The interphase genome is mainly shaped by cohesin-mediated loop extrusion and cohesin-
independent compartmentalization. Extrusion is a dynamic process of cohesin loading, loop …

Abstract Background Lamina-associated domains (LADs) are large genomic regions that
are positioned at the nuclear lamina. It has remained largely unclear what drives the …