Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies

A Mandal, R Bisht, ID Rupenthal, AK Mitra - Journal of Controlled Release, 2017 - Elsevier
Effective intraocular drug delivery poses a major challenge due to the presence of various
elimination mechanisms and physiological barriers that result in low ocular bioavailability …

Strategies to address low drug solubility in discovery and development

HD Williams, NL Trevaskis, SA Charman… - Pharmacological …, 2013 - Elsevier
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Polymeric micelles as drug delivery vehicles

Z Ahmad, A Shah, M Siddiq, HB Kraatz - Rsc Advances, 2014 - pubs.rsc.org
Though much progress has been made in drug delivery systems, the design of a suitable
carrier for the delivery of hydrophobic drugs is still a major challenge for researchers. The …

In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery

K Al Khateb, EK Ozhmukhametova, MN Mussin… - International journal of …, 2016 - Elsevier
This study evaluated the use of Pluronic F127 and Pluronic F68 as excipients for formulating
in situ gelling systems for ocular drug delivery. Thermal transitions have been studied in …

Encapsulation of thymus vulgaris essential oil in caseinate/gelatin nanocomposite hydrogel: In vitro antibacterial activity and in vivo wound healing potential

SA Alsakhawy, HH Baghdadi, MA El-Shenawy… - International Journal of …, 2022 - Elsevier
Essential oils, derived from aromatic plants, exhibit various pharmacological properties.
Nevertheless, their clinical applications are confronted by various limitations, such as …

Direct and reverse pluronic micelles: Design and characterization of promising drug delivery nanosystems

A Naharros-Molinero, MÁ Caballo-González… - Pharmaceutics, 2022 - mdpi.com
Pluronics are a family of amphiphilic block copolymers broadly explored in the
pharmaceutical field. Under certain conditions, Pluronics self-assemble in different …

Polyelectrolyte–surfactant complexes as a formulation tool for drug delivery

M Gradzielski - Langmuir, 2022 - ACS Publications
Aqueous polyelectrolyte–surfactant complexes (PESCs) are very rich with respect to their
properties and the structures formed by them. By design they normally contain hydrophobic …

Nanomaterials for ocular drug delivery

S Liu, L Jones, FX Gu - Macromolecular bioscience, 2012 - Wiley Online Library
Efficient drug delivery to the eye remains a challenging task for pharmaceutical scientists.
Due to the various anatomical barriers and the clearance mechanisms prevailing in the eye …

Pluronic-based nanovehicles: Recent advances in anticancer therapeutic applications

I Jarak, CL Varela, ET da Silva, FFM Roleira… - European Journal of …, 2020 - Elsevier
Pluronics are a class of amphiphilic tri-block copolymers with wide pharmaceutical
applicability. In the past decades, the ability to form biocompatible nanosized micelles was …

Synthesis and characterization of low-toxic amphiphilic chitosan derivatives and their application as micelle carrier for antitumor drug

M Huo, Y Zhang, J Zhou, A Zou, D Yu, Y Wu… - International journal of …, 2010 - Elsevier
A new series of amphiphilically modified chitosan molecules with long alkyl chains as
hydrophobic moieties and glycol groups as hydrophilic moieties (N-octyl-O-glycol chitosan …