Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies
Effective intraocular drug delivery poses a major challenge due to the presence of various
elimination mechanisms and physiological barriers that result in low ocular bioavailability …
elimination mechanisms and physiological barriers that result in low ocular bioavailability …
Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
Polymeric micelles as drug delivery vehicles
Though much progress has been made in drug delivery systems, the design of a suitable
carrier for the delivery of hydrophobic drugs is still a major challenge for researchers. The …
carrier for the delivery of hydrophobic drugs is still a major challenge for researchers. The …
In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery
K Al Khateb, EK Ozhmukhametova, MN Mussin… - International journal of …, 2016 - Elsevier
This study evaluated the use of Pluronic F127 and Pluronic F68 as excipients for formulating
in situ gelling systems for ocular drug delivery. Thermal transitions have been studied in …
in situ gelling systems for ocular drug delivery. Thermal transitions have been studied in …
Encapsulation of thymus vulgaris essential oil in caseinate/gelatin nanocomposite hydrogel: In vitro antibacterial activity and in vivo wound healing potential
SA Alsakhawy, HH Baghdadi, MA El-Shenawy… - International Journal of …, 2022 - Elsevier
Essential oils, derived from aromatic plants, exhibit various pharmacological properties.
Nevertheless, their clinical applications are confronted by various limitations, such as …
Nevertheless, their clinical applications are confronted by various limitations, such as …
Direct and reverse pluronic micelles: Design and characterization of promising drug delivery nanosystems
A Naharros-Molinero, MÁ Caballo-González… - Pharmaceutics, 2022 - mdpi.com
Pluronics are a family of amphiphilic block copolymers broadly explored in the
pharmaceutical field. Under certain conditions, Pluronics self-assemble in different …
pharmaceutical field. Under certain conditions, Pluronics self-assemble in different …
Polyelectrolyte–surfactant complexes as a formulation tool for drug delivery
M Gradzielski - Langmuir, 2022 - ACS Publications
Aqueous polyelectrolyte–surfactant complexes (PESCs) are very rich with respect to their
properties and the structures formed by them. By design they normally contain hydrophobic …
properties and the structures formed by them. By design they normally contain hydrophobic …
Nanomaterials for ocular drug delivery
Efficient drug delivery to the eye remains a challenging task for pharmaceutical scientists.
Due to the various anatomical barriers and the clearance mechanisms prevailing in the eye …
Due to the various anatomical barriers and the clearance mechanisms prevailing in the eye …
Pluronic-based nanovehicles: Recent advances in anticancer therapeutic applications
I Jarak, CL Varela, ET da Silva, FFM Roleira… - European Journal of …, 2020 - Elsevier
Pluronics are a class of amphiphilic tri-block copolymers with wide pharmaceutical
applicability. In the past decades, the ability to form biocompatible nanosized micelles was …
applicability. In the past decades, the ability to form biocompatible nanosized micelles was …
Synthesis and characterization of low-toxic amphiphilic chitosan derivatives and their application as micelle carrier for antitumor drug
M Huo, Y Zhang, J Zhou, A Zou, D Yu, Y Wu… - International journal of …, 2010 - Elsevier
A new series of amphiphilically modified chitosan molecules with long alkyl chains as
hydrophobic moieties and glycol groups as hydrophilic moieties (N-octyl-O-glycol chitosan …
hydrophobic moieties and glycol groups as hydrophilic moieties (N-octyl-O-glycol chitosan …