Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ9-THC: mechanism underlying greater toxicity?

WE Fantegrossi, JH Moran, A Radominska-Pandya… - Life sciences, 2014 - Elsevier
K2 or Spice products are emerging drugs of abuse that contain synthetic cannabinoids
(SCBs). Although assumed by many teens and first time drug users to be a “safe” and “legal” …

Moving around the molecule: relationship between chemical structure and in vivo activity of synthetic cannabinoids

JL Wiley, JA Marusich, JW Huffman - Life sciences, 2014 - Elsevier
Originally synthesized for research purposes, indole-and pyrrole-derived synthetic
cannabinoids are the most common psychoactive compounds contained in abused products …

Novel psychoactive substances of interest for psychiatry

F Schifano, L Orsolini, G Duccio Papanti… - World …, 2015 - Wiley Online Library
Novel psychoactive substances include synthetic cannabinoids, cathinone derivatives,
psychedelic phenethylamines, novel stimulants, synthetic opioids, tryptamine derivatives …

Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135

SD Banister, J Stuart, RC Kevin… - ACS Chemical …, 2015 - ACS Publications
Synthetic cannabinoid (SC) designer drugs featuring bioisosteric fluorine substitution are
identified by forensic chemists and toxicologists with increasing frequency. Although …

From JWH‐018 to OXIZIDS: structural evolution of synthetic cannabinoids in the European Union from 2008 to present day

R Andrews, R Jorge, R Christie… - Drug testing and …, 2023 - Wiley Online Library
With new synthetic cannabinoids (SCs) appearing on the European drug market every year,
early warning systems are key to detect, monitor, and respond to threats posed by them. The …

Pharmacological and toxicological effects of synthetic cannabinoids and their metabolites

S Tai, WE Fantegrossi - … of New Psychoactive Substances (NPS) The …, 2017 - Springer
Commercial preparations containing synthetic cannabinoids (SCBs) are rapidly emerging as
drugs of abuse. Although often assumed to be “safe” and “legal” alternatives to cannabis …

Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and …

N Uchiyama, S Matsuda, M Kawamura… - Forensic …, 2013 - Springer
We identified two new-type cannabimimetic quinolinyl carboxylates, quinolin-8-yl 1-pentyl-(1
H-indole)-3-carboxylate (QUPIC, 1) and quinolin-8-yl 1-(cyclohexylmethyl)-1 H-indole-3 …

Next generation of novel psychoactive substances on the horizon–A complex problem to face

JB Zawilska, D Andrzejczak - Drug and Alcohol Dependence, 2015 - Elsevier
Background The last decade has seen a rapid and continuous growth in the availability and
use of novel psychoactive substances (NPS) across the world. Although various products …

Synthetic cannabinoids: analysis and metabolites

MA ElSohly, W Gul, AS Wanas, MM Radwan - Life sciences, 2014 - Elsevier
Cannabimimetics (commonly referred to as synthetic cannabinoids), a group of compounds
encompassing a wide range of chemical structures, have been developed by scientists with …

The chemistry and pharmacology of synthetic cannabinoid receptor agonists as new psychoactive substances: origins

SD Banister, M Connor - New Psychoactive Substances: Pharmacology …, 2018 - Springer
Synthetic cannabinoid receptor agonists (SCRAs) have proliferated as new psychoactive
substances (NPS) over the past decade. Relative to other classes of NPS, SCRAs are …