The liver performs a multitude of bodily functions, whilst retaining the ability to regenerate
damaged tissue. In this review, we discuss sex steroid biology, regulation of mammalian …

Sexual dimorphism is associated not only with somatic and behavioral differences between
men and women, but also with physiological differences reflected in organ metabolism …

Owing to environmental health concerns, a number of per-and polyfluoroalkyl substances
(PFAS) have been phased-out, and increasingly replaced by various chemical analogs …

The fine-tuning of glucose uptake mechanisms is rendered by various glucose transporters
with distinct transport characteristics. In the pancreatic islet, facilitative diffusion glucose …

The prevalence of obesity among children, adolescents and adults has been dramatically
increasing worldwide during the last several decades. The obesity epidemic has been …

Circulating fibroblast growth factor 21 (FGF21) levels are elevated in diabetic subjects and
correlate directly with abnormal glucose metabolism, while pharmacologically administered …

The nuclear receptor peroxisome proliferator-activated receptor γ (PPAR-γ) is an important
target in diabetes therapy, but its direct role, if any, in the restoration of islet function has …

Pancreatic ductal adenocarcinoma (PDAC) is the fourth cause of cancer death with an
overall survival of 5% at five years. The development of PDAC is characteristically …

Fibroblast growth factor (FGF) 21 is a distinctive member of the FGF family that functions as
an endocrine factor. It is expressed predominantly in the liver, but is also found in adipose …

The pathogenesis of type 2 diabetes mellitus involves both peripheral insulin resistance and
dysfunctional insulin secretion from the pancreatic β cell. Currently, there is intense research …