Acinar cell plasticity and development of pancreatic ductal adenocarcinoma
P Storz - Nature reviews Gastroenterology & hepatology, 2017 - nature.com
Acinar cells in the adult pancreas show high plasticity and can undergo transdifferentiation
to a progenitor-like cell type with ductal characteristics. This process, termed acinar-to-ductal …
to a progenitor-like cell type with ductal characteristics. This process, termed acinar-to-ductal …
Genetics and biology of pancreatic ductal adenocarcinoma
AF Hezel, AC Kimmelman, BZ Stanger… - Genes & …, 2006 - genesdev.cshlp.org
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the
United States with a median survival of< 6 mo and a dismal 5-yr survival rate of 3%–5%. The …
United States with a median survival of< 6 mo and a dismal 5-yr survival rate of 3%–5%. The …
Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …
Altered RNA splicing by mutant p53 activates oncogenic RAS signaling in pancreatic cancer
LF Escobar-Hoyos, A Penson, R Kannan, H Cho… - Cancer cell, 2020 - cell.com
Pancreatic ductal adenocarcinoma (PDAC) is driven by co-existing mutations in KRAS and
TP53. However, how these mutations collaborate to promote this cancer is unknown. Here …
TP53. However, how these mutations collaborate to promote this cancer is unknown. Here …
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
Pancreatic ductal adenocarcinoma (PDA), one of the deadliest human cancers, often
involves somatic activation of K-Ras oncogenes. We report that selective expression of an …
involves somatic activation of K-Ras oncogenes. We report that selective expression of an …
[HTML][HTML] Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids
The exocrine pancreas, consisting of ducts and acini, is the site of origin of pancreatitis and
pancreatic ductal adenocarcinoma (PDAC). Our understanding of the genesis and …
pancreatic ductal adenocarcinoma (PDAC). Our understanding of the genesis and …
Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma
S Murakami, D Shahbazian, R Surana, W Zhang… - Oncogene, 2017 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a high degree of
inflammation and profound immune suppression. Here we identify Yes-associated protein …
inflammation and profound immune suppression. Here we identify Yes-associated protein …
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
Pancreatic ductal adenocarcinoma (PDAC) is believed to arise through a multistep model
comprised of putative precursor lesions known as pancreatic intraepithelial neoplasia …
comprised of putative precursor lesions known as pancreatic intraepithelial neoplasia …
Pancreatic intraepithelial neoplasia
Most pancreatic cancers are not diagnosed until after the cancer has spread to other organs
and is no longer curable. As a result, the death rate for pancreatic cancer in this country …
and is no longer curable. As a result, the death rate for pancreatic cancer in this country …
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
JP De La O, LL Emerson… - Proceedings of the …, 2008 - National Acad Sciences
Efforts to model pancreatic cancer in mice have focused on mimicking genetic changes
found in the human disease, particularly the activating KRAS mutations that occur in …
found in the human disease, particularly the activating KRAS mutations that occur in …