Toxicity testing in the 21st century: progress in the past decade and future perspectives

D Krewski, ME Andersen, MG Tyshenko… - Archives of …, 2020 - Springer
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

[HTML][HTML] Relationships between vitamin D, gut microbiome, and systemic autoimmunity

EA Yamamoto, TN Jørgensen - Frontiers in immunology, 2020 - frontiersin.org
There is increasing recognition of the role the microbiome plays in states of health and
disease. Microbiome studies in systemic autoimmune diseases demonstrate unique …

PubChem in 2021: new data content and improved web interfaces

S Kim, J Chen, T Cheng, A Gindulyte, J He… - Nucleic acids …, 2021 - academic.oup.com
Abstract PubChem (https://pubchem. ncbi. nlm. nih. gov) is a popular chemical information
resource that serves the scientific community as well as the general public, with millions of …

PubChem 2019 update: improved access to chemical data

S Kim, J Chen, T Cheng, A Gindulyte, J He… - Nucleic acids …, 2019 - academic.oup.com
Abstract PubChem (https://pubchem. ncbi. nlm. nih. gov) is a key chemical information
resource for the biomedical research community. Substantial improvements were made in …

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

R Malik, G Chauhan, M Traylor, M Sargurupremraj… - Nature …, 2018 - nature.com
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Breast milk-derived human milk oligosaccharides promote Bifidobacterium interactions within a single ecosystem

MAE Lawson, IJ O'Neill, M Kujawska… - The ISME …, 2020 - academic.oup.com
Diet-microbe interactions play an important role in modulating the early-life microbiota, with
Bifidobacterium strains and species dominating the gut of breast-fed infants. Here, we …

The 3D Genome Browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions

Y Wang, F Song, B Zhang, L Zhang, J Xu, D Kuang… - Genome biology, 2018 - Springer
Here, we introduce the 3D Genome Browser, http://3dgenome. org, which allows users to
conveniently explore both their own and over 300 publicly available chromatin interaction …

NCBI GEO: archive for functional genomics data sets—update

T Barrett, SE Wilhite, P Ledoux… - Nucleic acids …, 2012 - academic.oup.com
Abstract The Gene Expression Omnibus (GEO, http://www. ncbi. nlm. nih. gov/geo/) is an
international public repository for high-throughput microarray and next-generation sequence …

Chemical Similarity Enrichment Analysis (ChemRICH) as alternative to biochemical pathway mapping for metabolomic datasets

DK Barupal, O Fiehn - Scientific reports, 2017 - nature.com
Metabolomics answers a fundamental question in biology: How does metabolism respond to
genetic, environmental or phenotypic perturbations? Combining several metabolomics …

Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq–based resource for pain and sensory neuroscience research

P Ray, A Torck, L Quigley, A Wangzhou, M Neiman… - Pain, 2018 - journals.lww.com
2. Methods We performed RNA-seq for hDRG and integratively analyzed the transcriptome
by comparing it with publicly available human and mouse RNA-seq data sets (sources …