Type A mesoionic compounds (1980–2020)

CA Ramsden, F Dumitrascu - Advances in Heterocyclic Chemistry, 2022 - Elsevier
Type A mesoionic compounds are of particular interest due to their participation in
synthetically useful 1, 3-dipolar cycloaddition reactions. This review covers the chemistry of …

Design, Synthesis, and Pharmacological Evaluation of N-Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active …

AE Kümmerle, M Schmitt, SVS Cardozo… - Journal of medicinal …, 2012 - ACS Publications
Among a small series of tested N-acylhydrazones (NAHs), the compound 8a was selected
as a selective submicromolar phosphodiesterase-4 (PDE4) inhibitor associated with anti …

Sequential cyclizations of 2-isothiocyanatobenzonitrile and 2-isocyanatobenzonitrile with α-aminoketones

P Langer, A Bodtke - Tetrahedron letters, 2003 - Elsevier
Sequential cyclizations of 2-isothiocyanatobenzonitrile and 2-isocyanatobenzonitrile with α-aminoketones
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Metal-free synthesis of benzimidazo [1, 2-c] quinazolin-6-ones with indole and benzenediamine oxidized by I2/TBHP

Z Dai, S Li, Y Li, L Feng, C Ma - Tetrahedron, 2019 - Elsevier
Abstract A variety of benzimidazo [1, 2-c] quinazolin-6-ones derivatives can be accessed in
moderate to good yields under simple and metal-free reaction conditions using indoles and …

One‐pot synthesis of quinazoline‐2,4(1H,3H)‐diones and 2‐thioxoquinazolinones with the aid of low‐valent titanium reagent

GL Dou, MM Wang, ZB Huang, DQ Shi - Journal of Heterocyclic …, 2009 - cir.nii.ac.jp
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Synthesis of imidazo [1, 2-c] quinazolin-5 (6H)-ones and benzimidazo [1, 2-c] quinazolin-6 (5H)-ones with the aid of low-valent titanium reagent.

X Zhao, DQ Shi - Journal of Heterocyclic Chemistry, 2010 - search.ebscohost.com
Abstract &lt; GRAPHIC&gt; &lt;/GRAPHIC&gt; A short and facile synthesis of imidazo [1, 2-c]
quinazolin-5 (6H)-ones and benzimidazo [1, 2-c] quinazolin-6 (5H)-ones was accomplished …

Domino Cyclization of 2‐Isothiocyanatobenzonitrile with Carboxylic Hydrazides − One‐Pot Synthesis of 1,2,4‐Triazolo[1,5‐c]quinazoline‐5(6H)‐thiones

J Blank, M Kandt, WD Pfeiffer… - European Journal of …, 2003 - Wiley Online Library
One‐pot reactions between carboxylic hydrazides and 2‐isothiocyanatobenzonitrile
afforded pharmacologically relevant 1, 2, 4‐triazolo [1, 5‐c] quinazoline‐5 (6H)‐thiones in …

Synthesis of 5-thioxo-6H-imidazo [1, 2-c] quinazolines and related compounds based on cyclocondensations of 2-isothiocyanatobenzonitrile (ITCB) with α …

A Bodtke, WD Pfeiffer, H Görls, H Dollinger, P Langer - Tetrahedron, 2007 - Elsevier
Pharmacologically relevant 5-thioxo-6H-imidazo [1, 2-c] quinazolines and 5-oxo-6H-imidazo
[1, 2-c] quinazolines were prepared by sequential reactions of α-aminoketones with 2 …

Development of a practical synthetic route of a PDE V inhibitor KF31327

K Fujino, H Takami, T Atsumi, T Ogasa… - … Process Research & …, 2001 - ACS Publications
An efficient route suitable for a large-scale preparation of KF31327 (1), a potent
phosphodiesterase V inhibitor, has been developed. We selected 7-chloro-2, 4 (1 H, 3 H) …

Sequential cyclizations of 2-isothiocyanatobenzonitrile with α-aminocarboxylic esters and acids

P Langer, A Bodtke - Synlett, 2003 - thieme-connect.com
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