Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

Regulated fibroblast growth factor (FGF) signalling is a prerequisite for the correct
development and homeostasis of articular cartilage, as evidenced by the fact that aberrant …

The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show
that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires …

Members of the fibroblast growth factor (FGF) family play pleiotropic roles in cellular and
metabolic homeostasis. During evolution, the ancestor FGF expands into multiple members …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Several members of the FGF family have been identified as potential regulators of glucose
homeostasis. We previously reported that a low threshold of FGF-induced FGF receptor 1c …

Abstract Phosphoinositide-specific phospholipase Cs (PLCs) are expressed in all
mammalian cells and play critical roles in signal transduction. To obtain a comprehensive …

Direct activation of the human phospholipase C-γ isozymes (PLC-γ1,-γ2) by tyrosine
phosphorylation is fundamental to the control of diverse biological processes, including …

The recruitment of signaling proteins into activated receptor tyrosine kinases (RTKs) to
produce rapid, high-fidelity downstream response is exposed to the ambiguity of random …

Musculoskeletal injuries and bone defects represent a significant clinical challenge,
necessitating innovative approaches for effective bone tissue regeneration. In this study, we …