Standardization of brain MR images across machines and protocols: bridging the gap for MRI-based radiomics

A Carré, G Klausner, M Edjlali, M Lerousseau… - Scientific reports, 2020 - nature.com
Radiomics relies on the extraction of a wide variety of quantitative image-based features to
provide decision support. Magnetic resonance imaging (MRI) contributes to the …

The University of Pennsylvania glioblastoma (UPenn-GBM) cohort: advanced MRI, clinical, genomics, & radiomics

S Bakas, C Sako, H Akbari, M Bilello, A Sotiras… - Scientific data, 2022 - nature.com
Glioblastoma is the most common aggressive adult brain tumor. Numerous studies have
reported results from either private institutional data or publicly available datasets. However …

Integrated biophysical modeling and image analysis: application to neuro-oncology

A Mang, S Bakas, S Subramanian… - Annual review of …, 2020 - annualreviews.org
Central nervous system (CNS) tumors come with vastly heterogeneous histologic,
molecular, and radiographic landscapes, rendering their precise characterization …

The oncogenic role of tubulin alpha-1c chain in human tumours

X Hu, H Zhu, B Chen, X He, Y Shen, X Zhang, Y Xu… - BMC cancer, 2022 - Springer
Tubulin alpha-1c chain (TUBA1C), a subtype of α-tubulin, has been shown to be involved in
cell proliferation and cell cycle progression in several cancers and to influence cancer …

Advanced imaging and computational techniques for the diagnostic and prognostic assessment of malignant gliomas

JR Bapuraj, N Wang, A Srinivasan, A Rao - The Cancer Journal, 2021 - journals.lww.com
Advanced imaging techniques provide a powerful tool to assess the intratumoral and
intertumoral heterogeneity of gliomas. Advances in the molecular understanding of glioma …

Accurate and robust alignment of differently stained histologic images based on greedy diffeomorphic registration

L Venet, S Pati, MD Feldman, MLP Nasrallah… - Applied Sciences, 2021 - mdpi.com
Histopathologic assessment routinely provides rich microscopic information about tissue
structure and disease process. However, the sections used are very thin, and essentially …

A pilot radiogenomic study of DIPG reveals distinct subgroups with unique clinical trajectories and therapeutic targets

X Zhu, MA Lazow, A Schafer, A Bartlett… - Acta Neuropathologica …, 2021 - Springer
An adequate understanding of the relationships between radiographic and genomic
features in diffuse intrinsic pontine glioma (DIPG) is essential, especially in the absence of …

Accurate and robust alignment of variable-stained histologic images using a general-purpose greedy diffeomorphic registration tool

L Venet, S Pati, P Yushkevich, S Bakas - arXiv preprint arXiv:1904.11929, 2019 - arxiv.org
Variously stained histology slices are routinely used by pathologists to assess extracted
tissue samples from various anatomical sites and determine the presence or extent of a …

Relating global and local connectome changes to dementia and targeted gene expression in Alzheimer's disease

SSM Elsheikh, ER Chimusa… - Frontiers in human …, 2021 - frontiersin.org
Networks are present in many aspects of our lives, and networks in neuroscience have
recently gained much attention leading to novel representations of brain connectivity. The …

System analysis based on the migration-and invasion-related gene sets identifies the infiltration-related genes of glioma

S Shi, J Zhong, W Peng, H Yin, D Zhong, H Cui… - Frontiers in …, 2023 - frontiersin.org
The current database has no information on the infiltration of glioma samples. Here, we
assessed the glioma samples' infiltration in The Cancer Gene Atlas (TCGA) through the …