Although classically known as an endocrine signal produced by the ovary, 17β-estradiol (E
2) is also a neurosteroid produced in neurons and astrocytes in the brain of many different …

Steroid hormones synthesized in and secreted from peripheral endocrine glands pass
through the blood‐brain barrier and play a role in the central nervous system. In addition, the …

Testosterone plays an essential role in sexual differentiation of the male sheep brain. The
ovine sexually dimorphic nucleus (oSDN), is 2 to 3 times larger in males than in females …

Simple Summary Brain aging in mammals is characterized by morphological and functional
changes in neural cells. This process, although physiological, leads to progressive cerebral …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease involving motor neurons
in the motor cortex, brainstem and spinal cord. ALS leads to progressive, aggravated muscle …

Aromatase, the enzyme converting androgens into estrogens, is involved in many brain
processes such as neural differentiation and plasticity or the prevention of cell death. We …

In recent years, omic analyses have been proposed as possible approaches to diagnosis, in
particular for tumours, as they should be able to provide quantitative tools to detect and …

OBJECTIVE: This research reports the expression of topoisomerase βII in fetal sheep
neuronal cells. The β isoform of DNA topoisomerase II plays a role in DNA repair process in …

Brain aging in mammals is characterized by morphological and functional changes of neural
cells. Macroscopically, this process leading to progressive cerebral volume loss and …

A possible response to aging is autophagy, a self-digestion process in which portions of
cytoplasm are encapsulated by double-membrane-bound structures and delivered to …