PLGA/PLA-based long-acting injectable depot microspheres in clinical use: production and characterization overview for protein/peptide delivery

A Butreddy, RP Gaddam, N Kommineni… - International journal of …, 2021 - mdpi.com
Over the past few decades, long acting injectable (LAI) depots of polylactide-co-glycolide
(PLGA) or polylactic acid (PLA) based microspheres have been developed for controlled …

Formulation composition, manufacturing process, and characterization of poly (lactide-co-glycolide) microparticles

K Park, A Otte, F Sharifi, J Garner, S Skidmore… - Journal of Controlled …, 2021 - Elsevier
Injectable long-acting formulations, specifically poly (lactide-co-glycolide)(PLGA) based
systems, have been used to deliver drugs systemically for up to 6 months. Despite the …

Challenges and Complications of Poly(lactic-co-glycolic acid)-Based Long-Acting Drug Product Development

YW Lim, WS Tan, KL Ho, AR Mariatulqabtiah… - Pharmaceutics, 2022 - mdpi.com
Poly (lactic-co-glycolic acid)(PLGA) is one of the preferred polymeric inactive ingredients for
long-acting parenteral drug products that are constituted of complex formulations. Despite …

Current trends in PLGA based long-acting injectable products: The industry perspective

OS Muddineti, A Omri - Expert Opinion on Drug Delivery, 2022 - Taylor & Francis
Introduction Poly (lactic-co-glycolic acid)(PLGA) has been used in many long-acting drug
formulations, which have been approved by the US Food and Drug Administration (FDA) …

Particle engineering principles and technologies for pharmaceutical biologics

D Cun, C Zhang, H Bera, M Yang - Advanced Drug Delivery Reviews, 2021 - Elsevier
The global market of pharmaceutical biologics has expanded significantly during the last few
decades. Currently, pharmaceutical biologic products constitute an indispensable part of the …

Green assessment of polymer microparticles production processes: a critical review

H El Itawi, S Fadlallah, F Allais, P Perré - Green Chemistry, 2022 - pubs.rsc.org
The fabrication of simple and core–shell polymer microparticles is of great importance due to
their wide range of industrial applications, such as in the food industry, cosmetics, and drug …

Nanostructured lipid carriers enriched hydrogels for skin topical administration of quercetin and omega-3 fatty acid

M Lúcio, N Giannino, S Barreira, J Catita, H Gonçalves… - Pharmaceutics, 2023 - mdpi.com
Chronic skin exposure to external hostile agents (eg, UV radiation, microorganisms, and
oxidizing chemicals) may increase oxidative stress, causing skin damage and aging …

Fabrication of PEG-PLGA microparticles with tunable sizes for controlled drug release application

PNK Sagoe, EJM Velázquez, YM Espiritusanto… - Molecules, 2023 - mdpi.com
Polymeric microparticles of polyethyleneglycol-polylactic acid-co-glycolic acid (PEG-PLGA)
are widely used as drug carriers for a variety of applications due to their unique …

Modeling the kinetics of lymph node retention and exposure of a cargo protein delivered by biotin-functionalized nanoparticles

PR Hartmeier, JL Kosanovich, KY Velankar… - Acta biomaterialia, 2023 - Elsevier
Generation of protective immunity through vaccination arises from the adaptive immune
response developed primarily in the lymph nodes drained from the immunization site …

Exploration of surface tension measurement methods for pharmaceutical excipients

Y Li, J Shi, X Zhang, M Ji, Y Ni, R Han, Z Li… - International Journal of …, 2024 - Elsevier
Surface tension is a crucial functional indicator for various classes of pharmaceutical
excipients, as highlighted in both the Pharmacopoeia of the People's Republic of China …