Obesity, diabetes mellitus, hypertension and cardiovascular disease are risk factors for
chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is …

Imidazole was first synthesized by Heinrich Debus in 1858 and was obtained by the reaction
of glyoxal and formaldehyde in ammonia, initially called glyoxaline. The current literature …

Acute inflammation is a localized and self-limited innate host-defense mechanism against
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …

Inflammation and its timely resolution are critical to ensure effective host defense and
appropriate tissue repair after injury and or infection. Chronic, unresolved inflammation …

We discuss the fascinating pharmacology of formylpeptide receptor 2 (FPR2; often referred
to as FPR2/ALX since it binds lipoxin A4). Initially identified as a low‐affinity 'relative'of …

Systemic, chronic, low-grade inflammation (SCLGI) underlies the pathogenesis of various
widespread diseases. It is often associated with bone loss, thus connecting chronic …

Renal microvascular disease associated with diabetes [Diabetic kidney disease-DKD] is the
leading cause of chronic kidney disease. In DKD, glomerular basement membrane …

One way to develop innovative approaches for the treatment of chronic diseases is to exploit
the biology of the resolution of inflammation. With this terminology, we identify the integrated …

Formyl peptide receptors (FPRs) comprise a class of chemoattractant pattern recognition
receptors, for which several physiological functions like host-defences, as well as the …

Under physiological conditions the initiation, duration and amplitude of inflammatory
responses are tightly regulated to ensure the restoration of homeostasis. The resolution of …