Antigen presentation by major histocompatibility complex (MHC) proteins is essential for
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that …

The major histocompatibility complex (MHC) loci are amongst the most polymorphic regions
in the genomes of vertebrates. In the human population, thousands of MHC gene variants …

Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II)
proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large …

Antigen presentation is a cellular process that involves a number of steps, beginning with
the production of peptides by proteolysis or aberrant synthesis and the delivery of peptides …

T cell receptor (TCR) recognition of antigenic peptides bound and presented by class I major
histocompatibility complex (MHC) proteins underlies the cytotoxic immune response to …

Adaptive sampling methods, often used in combination with Markov state models, are
becoming increasingly popular for speeding up rare events in simulation such as molecular …

Predicting the binding affinity of peptides able to interact with major histocompatibility
complex (MHC) molecules is a priority for researchers working in the identification of novel …

Molecular mimicry between foreign and self-antigens has been implicated as a cause of
autoimmune hepatitis in experimental models and cross-reacting antibodies in patients. This …

Viral diseases pose major threats to humans and other animals, including the billions of
chickens that are an important food source as well as a public health concern due to …

The loading of processed peptides on to major histocompatibility complex II (MHC-II)
molecules for recognition by T cells is vital to cell-mediated adaptive immunity. As part of this …