Deorphanizing caspase-3 and caspase-9 substrates in and out of apoptosis with deep substrate profiling

LE Araya, IV Soni, JA Hardy, O Julien - ACS chemical biology, 2021 - ACS Publications
Caspases are a family of enzymes that regulate biological processes such as inflammation
and programmed cell death, through proteolysis. For example, in the intrinsic pathway of …

RNF126‐Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple‐Negative Breast Cancer to Radiotherapy

W Liu, M Zheng, R Zhang, Q Jiang, G Du… - Advanced …, 2023 - Wiley Online Library
Triple‐negative breast cancer (TNBC) has higher molecular heterogeneity and metastatic
potential and the poorest prognosis. Because of limited therapeutics against TNBC …

RETRACTED: Silencing Long Non-coding RNA LINC01224 Inhibits Hepatocellular Carcinoma Progression via MicroRNA-330-5p-Induced Inhibition of CHEK1

D Gong, PC Feng, XF Ke, HL Kuang, LL Pan… - … Therapy-Nucleic Acids, 2020 - cell.com
Hepatocellular carcinoma (HCC) accounts for approximately 85%–90% of primary liver
cancers. Based on in silico analysis, differentially expressed long non-coding RNA (lncRNA) …

Targeting squalene epoxidase interrupts homologous recombination via the ER stress response and promotes radiotherapy efficacy

Z Hong, T Liu, L Wan, P Fa, P Kumar, Y Cao… - Cancer research, 2022 - AACR
Over 50% of all patients with cancer are treated with radiotherapy. However, radiotherapy is
often insufficient as a monotherapy and requires a nontoxic radiosensitizer. Squalene …

Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy

R Zhang, W Liu, J Sun, Y Kong, C Chen - Pharmacological Research, 2020 - Elsevier
The dysfunction of E3 ubiquitin ligases is important in the pathogenesis of many human
diseases, as they play important roles in multiple cellular processes. In this review, we …

A genome-wide pooled shRNA screen identifies PPP2R2A as a predictive biomarker for the response to ATR and CHK1 inhibitors

Z Qiu, P Fa, T Liu, CB Prasad, S Ma, Z Hong, ER Chan… - Cancer research, 2020 - AACR
There is currently a lack of precise predictive biomarkers for patient selection in clinical trials
of inhibitors targeting replication stress (RS) response proteins ATR and CHK1. The …

NEDD4 expression is associated with breast cancer progression and is predictive of a poor prognosis

L Wan, T Liu, Z Hong, Y Pan, ST Sizemore… - Breast Cancer …, 2019 - Springer
Background A role for neural precursor cell-expressed developmentally downregulated
gene 4 (NEDD4) in tumorigenesis has been suggested. However, information is lacking on …

Non-thermal plasma induces antileukemic effect through mTOR ubiquitination

SY Kim, HJ Kim, HJ Kim, CH Kim - Cells, 2020 - mdpi.com
Non-thermal plasma (NTP) has been studied as a novel therapeutic tool for cancer that does
not damage healthy cells. In this study, we show that N TP-treated solutions (NTS) can …

RNF126 as a marker of prognosis and proliferation of gastric cancer

K Migita, S Matsumoto, K Wakatsuki… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: Ring finger protein 126 (RNF126) belongs to the family of RING E3
ubiquitin ligases. Although RNF126 has been reported to be overexpressed in several …

Ring finger protein 126 promotes breast cancer metastasis and serves as a potential target to improve the therapeutic sensitivity of ATR inhibitors

Y Pan, Y Yang, R Huang, H Yang, Q Huang, Y Ji… - Breast Cancer …, 2022 - Springer
Background/aims This study explores the relationship between the E3 ubiquitin ligase Ring
finger protein 126 (RNF126) and early breast cancer metastasis and tests the hypothesis …