The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …

A large number of antibiotics are glycosides. In numerous cases the glycosidic residues are
crucial to their activity; sometimes, glycosylation only improves their pharmacokinetic …

Chemical Countermeasures for the Control of Bacterial Biofilms: Effective Compounds and
Promising Targets Page 1 Current Medicinal Chemistry, 2006, 13, 2163-2177 2163 …

Since the characterization of mRNA in 1961, our understanding of the roles of RNA
molecules has significantly grown. Beyond serving as a link between DNA and proteins …

The targeting of one mRNA in the transcriptome requires small molecules that bind with
substantial affinity and specificity. As such, compounds with specificity for individual RNA …

A key structural feature of the aminoglycoside antibiotics is a 1, 3-diaminocyclohexanetriol
termed streptamine or, in cases where the 2-hydroxy function is deoxygenated as in most …

A dimeric neomycin− neomycin conjugate 3 with a flexible linker, 2, 2′-(ethylenedioxy) bis
(ethylamine), has been synthesized and characterized. Dimer 3 can selectively bind to AT …

A new family of G-quadruplex ligands termed “amido phthalocyanines”(APcs) was
synthesized by reacting variable amino acids with tetraamino zinc phthalocyanine. Variation …

RNA is increasingly recognized for its significant functions in biological systems and has
recently become an important molecular target for therapeutics development …

Potent and selective recognition and modulation of disease-relevant RNAs remain a
daunting challenge. We previously examined the utility of the U1A N-terminal RNA …