Progress in stem cell therapy for spinal cord injury

L Gao, Y Peng, W Xu, P He, T Li, X Lu… - Stem Cells …, 2020 - Wiley Online Library
Background. Spinal cord injury (SCI) is one of the serious neurological diseases that occur
in young people with high morbidity and disability. However, there is still a lack of effective …

Current progress in the derivation and therapeutic application of neural stem cells

Y Tang, P Yu, L Cheng - Cell death & disease, 2017 - nature.com
Neural stem cells (NSCs) have a unique role in neural regeneration. Cell therapy based on
NSC transplantation is a promising tool for the treatment of nervous system diseases …

Restorative effects of human neural stem cell grafts on the primate spinal cord

ES Rosenzweig, JH Brock, P Lu, H Kumamaru… - Nature medicine, 2018 - nature.com
We grafted human spinal cord–derived neural progenitor cells (NPCs) into sites of cervical
spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug …

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

MM Pathak, JL Nourse, T Tran, J Hwe… - Proceedings of the …, 2014 - National Acad Sciences
Neural stem cells are multipotent cells with the ability to differentiate into neurons,
astrocytes, and oligodendrocytes. Lineage specification is strongly sensitive to the …

Purification and characterization of human neural stem and progenitor cells

DD Liu, JQ He, R Sinha, AE Eastman, AM Toland… - Cell, 2023 - cell.com
The human brain undergoes rapid development at mid-gestation from a pool of neural stem
and progenitor cells (NSPCs) that give rise to the neurons, oligodendrocytes, and astrocytes …

Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice

S Nori, Y Okada, A Yasuda, O Tsuji… - Proceedings of the …, 2011 - National Acad Sciences
Once their safety is confirmed, human-induced pluripotent stem cells (hiPSCs), which do not
entail ethical concerns, may become a preferred cell source for regenerative medicine …

Combinatorial therapies after spinal cord injury: how can biomaterials help?

T Führmann, PN Anandakumaran… - Advanced healthcare …, 2017 - Wiley Online Library
Traumatic spinal cord injury (SCI) results in an immediate loss of motor and sensory function
below the injury site and is associated with a poor prognosis. The inhibitory environment that …

Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition

S Nori, Y Okada, S Nishimura, T Sasaki, G Itakura… - Stem cell reports, 2015 - cell.com
Previously, we described the safety and therapeutic potential of neurospheres (NSs) derived
from a human induced pluripotent stem cell (iPSC) clone, 201B7, in a spinal cord injury …

Neural stem cell-derived exosomes facilitate spinal cord functional recovery after injury by promoting angiogenesis

D Zhong, Y Cao, CJ Li, M Li, ZJ Rong… - Experimental …, 2020 - journals.sagepub.com
Acute traumatic spinal cord injury is a devastating event without effective therapeutic
approach. The feeble plasticity of spinal cord microvascular endothelial cells (SCMECs) …

Advances in stem cell therapy for spinal cord injury

AJ Mothe, CH Tator - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
Spinal cord injury (SCI) is a devastating condition producing great personal and societal
costs and for which there is no effective treatment. Stem cell transplantation is a promising …