Computational analysis of cancer genome sequencing data
Distilling biologically meaningful information from cancer genome sequencing data requires
comprehensive identification of somatic alterations using rigorous computational methods …
comprehensive identification of somatic alterations using rigorous computational methods …
[HTML][HTML] Detection of genomic structural variants from next-generation sequencing data
Structural variants are genomic rearrangements larger than 50 bp accounting for around 1%
of the variation among human genomes. They impact on phenotypic diversity and play a role …
of the variation among human genomes. They impact on phenotypic diversity and play a role …
[HTML][HTML] Genetic and functional drivers of diffuse large B cell lymphoma
Diffuse large B cell lymphoma (DLBCL) is the most common form of blood cancer and is
characterized by a striking degree of genetic and clinical heterogeneity. This heterogeneity …
characterized by a striking degree of genetic and clinical heterogeneity. This heterogeneity …
SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer
Some cancers evade targeted therapies through a mechanism known as lineage plasticity,
whereby tumor cells acquire phenotypic characteristics of a cell lineage whose survival no …
whereby tumor cells acquire phenotypic characteristics of a cell lineage whose survival no …
[HTML][HTML] CNVkit: genome-wide copy number detection and visualization from targeted DNA sequencing
Germline copy number variants (CNVs) and somatic copy number alterations (SCNAs) are
of significant importance in syndromic conditions and cancer. Massively parallel sequencing …
of significant importance in syndromic conditions and cancer. Massively parallel sequencing …
Clonal evolution of glioblastoma under therapy
Glioblastoma (GBM) is the most common and aggressive primary brain tumor. To better
understand how GBM evolves, we analyzed longitudinal genomic and transcriptomic data …
understand how GBM evolves, we analyzed longitudinal genomic and transcriptomic data …
[HTML][HTML] Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution
The cancer immunoediting hypothesis postulates a dual role of the immune system:
protecting the host by eliminating tumor cells, and shaping the tumor by editing its genome …
protecting the host by eliminating tumor cells, and shaping the tumor by editing its genome …
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas
We report on whole-exome sequencing (WES) of 213 melanomas. Our analysis established
NF1, encoding a negative regulator of RAS, as the third most frequently mutated gene in …
NF1, encoding a negative regulator of RAS, as the third most frequently mutated gene in …
The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome
Sézary syndrome is a leukemic and aggressive form of cutaneous T cell lymphoma (CTCL)
resulting from the malignant transformation of skin-homing central memory CD4+ T cells …
resulting from the malignant transformation of skin-homing central memory CD4+ T cells …
A phase II trial of the aurora kinase a inhibitor alisertib for patients with castration-resistant and neuroendocrine prostate cancer: efficacy and biomarkers
H Beltran, C Oromendia, DC Danila… - Clinical Cancer …, 2019 - AACR
Purpose: Neuroendocrine prostate cancer (NEPC) is an aggressive variant of prostate
cancer that may develop de novo or as a mechanism of treatment resistance. N-myc is …
cancer that may develop de novo or as a mechanism of treatment resistance. N-myc is …