Non-alcoholic fatty liver disease (NAFLD)–pathogenesis, classification, and effect on drug metabolizing enzymes and transporters
E Cobbina, F Akhlaghi - Drug metabolism reviews, 2017 - Taylor & Francis
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders. It is defined by the
presence of steatosis in more than 5% of hepatocytes with little or no alcohol consumption …
presence of steatosis in more than 5% of hepatocytes with little or no alcohol consumption …
[HTML][HTML] Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation
We investigated the elimination routes for the 200 drugs that are sold most often by
prescription count in the United States. The majority (78%) of the hepatically cleared drugs …
prescription count in the United States. The majority (78%) of the hepatically cleared drugs …
Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in …
NJ Hewitt, MJ Gómez Lechón, JB Houston… - Drug metabolism …, 2007 - Taylor & Francis
This review brings you up-to-date with the hepatocyte research on: 1) in vitro–in vivo
correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross …
correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross …
Impact of infectious and inflammatory disease on cytochrome P450–mediated drug metabolism and pharmacokinetics
ET Morgan - Clinical Pharmacology & Therapeutics, 2009 - Wiley Online Library
Infection and inflammation are associated with downregulation of hepatic and extrahepatic
cytochrome P450s as well as other drug‐metabolizing enzymes and transporters. We review …
cytochrome P450s as well as other drug‐metabolizing enzymes and transporters. We review …
Human cytochrome P450 enzymes
FP Guengerich - Cytochrome P450: structure, mechanism, and …, 2015 - Springer
Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
Distinct effects of inflammation on cytochrome P450 regulation and drug metabolism: lessons from experimental models and a potential role for pharmacogenetics
Personalized medicine strives to optimize drug treatment for the individual patient by taking
into account both genetic and non-genetic factors for drug response. Inflammation is one of …
into account both genetic and non-genetic factors for drug response. Inflammation is one of …
Regulation of drug-metabolizing enzymes and transporters in inflammation
AE Aitken, TA Richardson… - Annu. Rev. Pharmacol …, 2006 - annualreviews.org
▪ Abstract Inflammation and infection have long been known to downregulate the activity and
expression of cytochrome P450 (CYP) enzymes involved in hepatic drug clearance. This …
expression of cytochrome P450 (CYP) enzymes involved in hepatic drug clearance. This …
The role of CYP3A in health and disease
LS Klyushova, ML Perepechaeva, AY Grishanova - Biomedicines, 2022 - mdpi.com
CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …
The role of cytochromes P450 in infection
E Stavropoulou, GG Pircalabioru… - Frontiers in …, 2018 - frontiersin.org
Cytochromes are expressed in many different tissues of the human body. They are found
mostly in intestinal and hepatic tissues. Cytochromes P450 (CYPs) are enzymes that oxidize …
mostly in intestinal and hepatic tissues. Cytochromes P450 (CYPs) are enzymes that oxidize …