In this work, we review clinical features and genetic diagnosis of diseases caused by
mutations in the gene encoding valosin-containing protein (VCP/p97), the functionally …

Many conditions can benefit from RNA-based therapies, namely, those targeting internal
ribosome entry sites (IRESs) and their regulatory proteins, the IRES trans-acting factors …

Human embryonic stem cells (hESCs) provide opportunities for cell replacement therapy of
insulin-dependent diabetes. Therapeutic quantities of human stem cell-derived islets (SC …

Neurodegeneration is the primary driver of disease progression in multiple sclerosis (MS)
resulting in permanent disability, creating an urgent need to discover its underlying …

The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is the most abundant and
ubiquitously expressed member of the heterogeneous nuclear ribonucleoproteins family …

Nuclear clearance of the RNA-binding protein TDP-43 is a hallmark of neurodegeneration
and an important therapeutic target. Our current understanding of TDP-43 …

Mitogen-activated protein kinase-interacting kinases 1 and 2 (MNK1/2) represent a central
class of enzymes that are activated by extracellular signal-regulated kinase (ERK) or p38 …

Amyotrophic lateral sclerosis is a fatal motor neuron degenerative disease. Multiple genetic
and non-genetic risk factors are associated with disease pathogenesis, and several cellular …

Protein dynamics play a crucial role in their diverse functions. The intracellular environment
significantly influences protein dynamics, particularly for intrinsically disordered proteins …

Aging represents the major risk factor for the onset and/or progression of various disorders
including neurodegenerative diseases, metabolic disorders, and bone-related defects. As …