ABC transporters are essential for cellular physiology. Humans have 48 ABC genes
organized into seven distinct families. Of these genes, 44 (in five distinct families) encode for …

ABCA4 is a member of the superfamily of ATP-binding cassette (ABC) transporters that is
preferentially localized along the rim region of rod and cone photoreceptor outer segment …

Abscisic acid (ABA) is a phytohormone essential to the regulation of numerous aspects of
plant growth and development. The cellular level of ABA is critical to its signalling and is …

Membrane proteins are a highly relevant class of biological molecules and comprise∼ 60%
of current drug targets. Before being analyzed by structural, biochemical, and biophysical …

Human ABC transporter ABCD1 transports very long-chain fatty acids from cytosol to
peroxisome for β-oxidation, dysfunction of which usually causes the X-linked …

Millions of people worldwide have hereditary genetic disorders, trauma, infectious diseases,
or cancer of the eyes, and many of these eye diseases lead to irreversible blindness, which …

Phospholipid extrusion by ABC subfamily A (ABCA) exporters is central to cellular
physiology, although the specifics of the underlying substrate interactions and transport …

Background ABCA4, the gene implicated in Stargardt disease (STGD1), contains 50 exons,
of which 17 contain multiples of three nucleotides. The impact of in-frame exon skipping is …

Stargardt disease is a currently untreatable, inherited neurodegenerative disease that leads
to macular degeneration and blindness due to loss-of-function mutations in the ABCA4 …

The adenosine 5′-triphosphate (ATP)–binding cassette (ABC) transporter ABCA3 plays a
critical role in pulmonary surfactant biogenesis. Mutations in human ABCA3 have been …