Neural stem and progenitor cells have a central role in the development and evolution of the
mammalian neocortex. In this review, we first provide a set of criteria to classify the various …

During vertebrate development, a wide variety of cell types and tissues emerge from a single
fertilized oocyte. One of these tissues, the central nervous system, contains many types of …

Targeting the androgen receptor (AR) signaling axis has been, over decades, the mainstay
of prostate cancer therapy. More potent inhibitors of androgen synthesis and antiandrogens …

Cortical intermediate progenitors (IPs) comprise a secondary neuronal progenitor pool that
arises from radial glia (RG). IPs are essential for generating the correct number of cortical …

The mammalian nervous system is the most complex organ of any living organism. How this
complexity is generated during neural development is just beginning to be elucidated. This …

The cerebral cortex is a complex structure that contains different classes of neurons
distributed within six layers and regionally organized into highly specialized areas. Cortical …

Cerebral cortical progenitor cells can be classified into several different types, and each
progenitor type integrates cell-intrinsic and cell-extrinsic cues to regulate neurogenesis. On …

Members of the Wnt family of secreted signaling proteins influence many aspects of neural
development and function. Wnts are required from neural induction and axis formation to …

Phosphatase and tensin homolog (PTEN) is a classical tumor suppressor that antagonizes
phosphatidylinositol 3-phosphate kinase (PI3K)/AKT signaling. Although there is a strong …

Components of the Wnt signaling pathway are expressed in a tightly regulated and spatially
specific manner during development of the forebrain, and Wnts are key regulators of …