Quantitative T2 and T1ρ mapping are sensitive to ischemic injury to the epiphyseal cartilage in an in vivo piglet model of Legg-Calvé-Perthes disease

AR Armstrong, S Bhave, EO Buko, KL Chase… - Osteoarthritis and …, 2022 - Elsevier
Objective To determine if the quantitative MRI techniques T2 and T1ρ mapping are sensitive
to ischemic injury to epiphyseal cartilage in vivo in a piglet model of Legg-Calvé-Perthes …

Intravoxel incoherent motion (IVIM) detects femoral head ischemia in a piglet model of Legg‐Calvé‐Perthes disease

EO Buko, S Bhave, S Moeller, JC Laine… - Journal of …, 2024 - Wiley Online Library
There is a clinical need for alternatives to gadolinium contrast‐enhanced magnetic
resonance imaging (MRI) to facilitate early detection and assessment of femoral head …

Detection of early metaphyseal changes in a piglet model of Legg‐Calvé‐Perthes disease using quantitative mapping of MRI relaxation times

EO Buko, AR Armstrong, JC Laine… - Journal of …, 2024 - Wiley Online Library
Abstract Legg‐Calvé‐Perthes disease (LCPD) is a childhood hip disorder characterized by
ischemic injury to the epiphysis of the femoral head, but changes to the metaphysis have …

Effects of acute femoral head ischemia on the growth plate and metaphysis in a piglet model of Legg-Calvé-Perthes disease

AR Armstrong, F Tóth, CS Carlson, HKW Kim… - Osteoarthritis and …, 2023 - Elsevier
Objective To determine the effects of acute (≤ 7 days) femoral head ischemia on the
proximal femoral growth plate and metaphysis in a piglet model of Legg-Calvé-Perthes …

Ischaemic chondronecrosis as a novel causative factor in the aetiopathogenesis of infantile Blount's disease

S Gangadharan - Medical Hypotheses, 2024 - Elsevier
Infantile Blount's disease primarily affects toddlers, leading to tibia vara with or without
growth arrest. While the disease's association with abnormal compressive forces on the …

Naturally occurring osteochondrosis latens lesions identified by quantitative and morphological 10.5 T MRI in pigs

AR Armstrong, Š Zbýň, AW Kajabi… - Journal of …, 2023 - Wiley Online Library
Juvenile osteochondritis dissecans (JOCD) is a pediatric orthopedic disorder that involves
the articular–epiphyseal cartilage complex and underlying bone. Clinical disease is often …

'One Medicine–One Pathology': Assessment and Validation of Animal Models of Orthopaedic Diseases

A Armstrong - 2022 - search.proquest.com
The projects presented here revolve around the utilization of three different animal models of
developmental and degenerative orthopaedic diseases, with the work described in order of …

MRI Relaxation Times Change in the Metaphysis Following Ischemic Injury to the Femoral Head: An In Vivo Piglet Model Study

E Buko, AR Armstrong, F Tóth, CP Johnson - archive.ismrm.org
Quantitative mapping of T2, T1ρ, adiabatic T1ρ, and adiabatic T2ρ relaxation times may be
useful to assess ischemic injury to the femoral head. In this work, we investigated whether …