Corticosteroids: mechanisms of action in health and disease

S Ramamoorthy, JA Cidlowski - Rheumatic Disease …, 2016 - rheumatic.theclinics.com
Corticosteroids are a class of steroid hormones released by the adrenal cortex, which
includes glucocorticoids and mineralocorticoids. 1 However, the term “corticosteroids” is …

A users guide to HPA axis research

RL Spencer, T Deak - Physiology & behavior, 2017 - Elsevier
Glucocorticoid hormones (cortisol and corticosterone-CORT) are the effector hormones of
the hypothalamic-pituitary-adrenal (HPA) axis neuroendocrine system. CORT is a systemic …

The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease

RH Oakley, JA Cidlowski - Journal of Allergy and Clinical Immunology, 2013 - Elsevier
Glucocorticoids are primary stress hormones necessary for life that regulate numerous
physiologic processes in an effort to maintain homeostasis. Synthetic derivatives of these …

Comprehensive overview of the structure and regulation of the glucocorticoid receptor

S Vandevyver, L Dejager, C Libert - Endocrine reviews, 2014 - academic.oup.com
Glucocorticoids are among the most prescribed drugs worldwide for the treatment of
numerous immune and inflammatory disorders. They exert their actions by binding to the …

The glucocorticoid receptor: cause of or cure for obesity?

K John, JS Marino, ER Sanchez… - American Journal of …, 2016 - journals.physiology.org
Glucocorticoid hormones (GCs) are important regulators of lipid metabolism, promoting
lipolysis with acute treatment but lipogenesis with chronic exposure. Conventional wisdom …

Glucocorticoid receptor β (GRβ): beyond its dominant-negative function

P Ramos-Ramírez, O Tliba - International Journal of Molecular Sciences, 2021 - mdpi.com
Glucocorticoids (GCs) act via the GC receptor (GR), a receptor ubiquitously expressed in the
body where it drives a broad spectrum of responses within distinct cell types and tissues …

Multifaceted control of GR signaling and its impact on hepatic transcriptional networks and metabolism

SM Præstholm, CM Correia, L Grøntved - Frontiers in Endocrinology, 2020 - frontiersin.org
Glucocorticoids (GCs) and the glucocorticoid receptor (GR) are important regulators of
development, inflammation, stress response and metabolism, demonstrated in various …

Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-activated Receptor (PPAR) α*♦

JS Marino, LA Stechschulte, DE Stec… - Journal of Biological …, 2016 - ASBMB
Glucocorticoids (GCs) regulate energy supply in response to stress by increasing hepatic
gluconeogenesis during fasting. Long-term GC treatment induces hepatic steatosis and …

The pro-inflammatory effects of glucocorticoids in the brain

EA Duque, CD Munhoz - Frontiers in endocrinology, 2016 - frontiersin.org
Glucocorticoids are a class of steroid hormones derived from cholesterol. Their actions are
mediated by the glucocorticoid and mineralocorticoid receptors, members of the superfamily …

The human placenta expresses multiple glucocorticoid receptor isoforms that are altered by fetal sex, growth restriction and maternal asthma

Z Saif, NA Hodyl, E Hobbs, AR Tuck, MS Butler… - Placenta, 2014 - Elsevier
Introduction We have previously identified sex-specific differences in the fetal-placental
response to cortisol. Our recent studies suggest that this differential response to cortisol is …