Focusing on the literature progress since 2002, the present review explores the highly
significant role that multicomponent reactions (MCRs) have played as a very important tool …

Oxindole has emerged as a valuable scaffold in medicinal chemistry possessing diverse
range of pharmacological activities. Its value has further been increased by its natural …

Spirocyclic compounds isolated from plant and animal origins have important applications in
medicinal chemistry. Spiro compounds having cyclic structures fused at a central carbon are …

Dipolar cycloaddition reactions can be considered a powerful synthetic tool in the building of
heterocyclic rings, with applications in different fields. In this review we focus on the …

This review summarizes the trends in the formation of complex or not so complex
heterocyclic structures through 1, 3-dipolar cycloadditions of azomethine ylides. Diastereo …

Nitrogen-containing heterocyclic compounds are some of the most significant compounds
that are produced artificially or naturally. These heterocyclic rings are virtually always …

Catalytic asymmetric construction of the biologically important spiro [pyrrolidin‐3, 2′‐
oxindole] scaffold with contiguous quaternary stereogenic centers in excellent …

3-Amino-2-oxindoles bearing tetra-substituted stereocenter are very important constituents
of many bioactive and pharmaceutical agents. In the last few years, asymmetric …

N-2, 2, 2-Trifluoroethylisatin ketimines with β-trifluoromethyl enones, 3-trifluoroethylidene
oxindole, and 3-trifluoroethylidene benzofuranone can undergo asymmetric [3+ 2] …

Novel spirooxindole–pyrrolidine compounds have been synthesised through 1, 3-dipolar
cycloaddition of azomethine ylides generated from isatin and sarcosine or thioproline with …