Schizosaccharomyces pombe (fission yeast) is an attractive model for mitochondrial
research. The organism resembles human cells in terms of mitochondrial inheritance …

How do cells age and die? For the past 20 years, the budding yeast, Saccharomyces
cerevisiae, has been used as a model organism to uncover the genes that regulate lifespan …

Fission yeasts are an ancient group of fungal species that diverged from each other from
tens to hundreds of million years ago. Among them is the preeminent model organism …

In eukaryotes, the wobble position of tRNA with a GUN anticodon is modified to the 7-deaza-
guanosine derivative queuosine (Q34), but the original source of Q is bacterial, since Q is …

The molecular mechanism of human mitochondrial translation has yet to be fully described.
We are particularly interested in understanding the process of translational termination and …

Glucose is the preferred carbon and energy source in prokaryotes, unicellular eukaryotes,
and metazoans. However, excess of glucose has been associated with several diseases …

When glucose is available, many organisms repress mitochondrial respiration in favour of
aerobic glycolysis, or fermentation in yeast, that suffices for ATP production. Fission yeast …

Gene essentiality is a variable phenotypic trait, but to what extent and how essential genes
can become dispensable for viability remain unclear. Here, we investigate 'bypass of …

The antiaging properties of metformin used for the treatment of type-2 diabetes mellitus have
been studied extensively, but there is more to discover regarding underlying mechanisms …

In the past years, simple organisms such as yeasts and worms have contributed a great deal
to aging research. Studies pioneered in Saccharomyces cerevisiae were useful to elucidate …