Covering: 2011 to 2014 It is widely accepted that drug discovery often requires a systems-
level polypharmacology approach to tackle problems such as lack of efficacy and emerging …

Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of
Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for …

Abstract Preclinical Research Network pharmacology, based on the theory of systems
biology, is a new discipline that analyzes the biological network and screens out the nodes …

Genome-wide expression profiling of gene transcripts has been successfully applied in
biomedical discovery for over a decade. Based on the premises of this technology …

Background: Massively parallel gene expression profiling has provided a more objective,
molecular-level characterization of breast cancer subtypes. Several bioinformatics tools are …

The one-drug/one-target/one-disease approach to drug discovery is presently facing many
challenges of safety, efficacy, and sustainability. Network biology and polypharmacology …

Gong, J., Yin, F., Hou, Y. and Yin, Y. 2014. Chinese herbs as alternatives to antibiotics in
feed for swine and poultry production: Potential and challenges in application. Can. J. Anim …

Omic techniques have become key tools in the development of systems biology. As the
holistic approaches underlying the practice of traditional Chinese medicine (TCM) and new …

Covering: up to 2014 In silico approaches have been widely recognised to be useful for drug
discovery. Here, we consider the significance of available databases of medicinal plants and …

Drug repositioning is a new way of applying the existing therapeutics to new disease
indications. Due to the exorbitant cost and high failure rate in developing new drugs, the …