Coagulopathy and haemorrhagic progression in traumatic brain injury: advances in mechanisms, diagnosis, and management

M Maegele, H Schöchl, T Menovsky… - The Lancet …, 2017 - thelancet.com
Normal haemostasis depends on an intricate balance between mechanisms of bleeding and
mechanisms of thrombosis, and this balance can be altered after traumatic brain injury (TBI) …

The European guideline on management of major bleeding and coagulopathy following trauma

DR Spahn, B Bouillon, V Cerny, J Duranteau… - Critical care, 2019 - Springer
Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

The European guideline on management of major bleeding and coagulopathy following trauma

R Rossaint, B Bouillon, V Cerny, TJ Coats, J Duranteau… - Critical care, 2016 - Springer
Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

Coagulopathy in traumatic brain injury and its correlation with progressive hemorrhagic injury: a systematic review and meta-analysis

Q Yuan, Y Sun, X Wu, J Yu, Z Li, Z Du, X Wu… - Journal of …, 2016 - liebertpub.com
The association between coagulopathy and either isolated traumatic brain injury (TBI) or
progressive hemorrhagic injury (PHI) remains controversial. The aims of this study were to …

Sympathoadrenal activation is associated with acute traumatic coagulopathy and endotheliopathy in isolated brain injury

AP Di Battista, SB Rizoli, B Lejnieks, A Min, MY Shiu… - Shock, 2016 - journals.lww.com
Background: Acute coagulopathy after traumatic brain injury (TBI) involves a complex
multifactorial hemostatic response that is poorly characterized. Objectives: To examine early …

Predicting progressive hemorrhagic injury from isolated traumatic brain injury and coagulation

LE Folkerson, D Sloan, BA Cotton, JB Holcomb… - Surgery, 2015 - Elsevier
Background Progressive hemorrhagic injury (PHI) in traumatic brain injury (TBI) patients is
associated with poor outcomes. Early prediction of PHI is difficult yet vital. We hypothesize …

Traumatic brain injury is associated with both hemorrhagic stroke and ischemic stroke: a systematic review and meta-analysis

D Qu, W Li, S Zhang, R Li, H Wang… - Frontiers in Neuroscience, 2022 - frontiersin.org
Background Traumatic brain injury (TBI) is considered a risk factor for the development of
stroke (Hemorrhagic Stroke and Ischemic Stroke). We performed this systemic review and …

Platelet-to-lymphocyte ratio predicts short-term mortality in patients with moderate to severe traumatic brain injury

W Li, W Deng - Scientific Reports, 2022 - nature.com
An easily accessible biomarker with good diagnostic power for patients with traumatic brain
injury (TBI) was needed to predict the short-term mortality. Studies have shown that platelet …

Prospective validation of the brain injury guidelines: managing traumatic brain injury without neurosurgical consultation

B Joseph, H Aziz, V Pandit, N Kulvatunyou… - Journal of Trauma …, 2014 - journals.lww.com
BACKGROUND To optimize neurosurgical resources, guidelines were developed at our
institution, allowing the acute care surgeons to independently manage traumatic intracranial …

Viscoelastic testing and coagulopathy of traumatic brain injury

JL Bradbury, SG Thomas, NR Sorg, N Mjaess… - Journal of clinical …, 2021 - mdpi.com
A unique coagulopathy often manifests following traumatic brain injury, leading the clinician
down a difficult decision path on appropriate prophylaxis and therapy. Conventional …