The year 2017 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …

The review by Christianson, published in 2017 on the twentieth anniversary of the
emergence of the field, summarizes the foundational discoveries and key advances in …

All known triterpenes are generated by triterpene synthases (TrTSs) from squalene or
oxidosqualene. This approach is fundamentally different from the biosynthesis of short-chain …

The cyclization of farnesyl diphosphate (FPP) into highly strained polycyclic sesquiterpenes
is challenging. We here determined the crystal structures of three sesquiterpene synthases …

Covering: up to 2015 This review summarises the accumulated knowledge about
characterised bacterial terpene cyclases. The structures of identified products and of …

Covering: up to July 2019 Terpene synthases (TSs) are responsible for generating much of
the structural diversity found in the superfamily of terpenoid natural products. These elegant …

Terpene synthases (TSs) catalyse the most complex cyclization cascades in nature, with
generation and taming of reactive carbocations. Although deprotonation–reprotonation …

This Minireview summarises recent developments in the biosynthesis of diterpenes by
diterpene synthases in bacteria. It is structured by the class of enzyme involved in the first …

Terpene cyclases (TCs), extraordinary enzymes that create the structural diversity seen in
terpene natural products, are traditionally divided into two classes, class I and class II …

Species of the Fusarium fujikuroi species complex (FFC) cause a wide spectrum of often
devastating diseases on diverse agricultural crops, including coffee, fig, mango, maize, rice …