Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In
particular, activation of calcium-and voltage-gated potassium channels of large conductance …

Arterioles in the peripheral microcirculation regulate blood flow to and within tissues and
organs, control capillary blood pressure and microvascular fluid exchange, govern …

Endothelial cells (ECs) line the lumen of all blood vessels and regulate functions, including
contractility. Physiological stimuli, such as acetylcholine (ACh) and intravascular flow …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes coronavirus
disease (COVID-19) is one of the most serious global health crises in recent history. COVID …

Background: Vascular endothelium and smooth muscle work together to keep the balance of
vasomotor tone and jointly maintain vascular homeostasis. Ca2+-permeable ion channel …

Rab GTPases, the largest family of small GTPases, are ubiquitously expressed proteins that
control various aspects of cellular function, from cell survival to exocytosis. Rabs cycle …

Rationale: Large-conductance calcium-activated potassium channels (BK) are composed of
pore-forming BKα and auxiliary β1 subunits in arterial smooth muscle cells (myocytes) …

A variety of ion channels regulate membrane potential and calcium influx in arterial smooth
muscle and endothelial cells to modify vascular functions, including contractility. The current …

Calcium-/voltage-gated, large-conductance potassium channels (BKs) control critical
physiological processes, including smooth muscle contraction. Numerous observations …

Hypertension is a risk factor for cerebrovascular diseases, including stroke and dementia.
During hypertension, arteries become constricted and are less responsive to vasodilators …