Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Populations with common physical diseases–such as cardiovascular diseases, cancer and
neurodegenerative disorders–experience substantially higher rates of major depressive …

Definition Apoptosis, programmed cell death, has a central role in developmental biology
and in maintaining the equilibrium of renewing tissues. A founding member of the Bcl-2 …

The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once
disrupted, it can lead to various pathological outcomes and diseases, such as depression …

Adequate oxygen supply is essential for the human brain to meet its high energy demands.
Therefore, elaborate molecular and systemic mechanism are in place to enable adaptation …

Neurons are particularly susceptible to energy fluctuations in response to stress.
Mitochondrial fission is highly regulated to generate ATP via oxidative phosphorylation; …

Background Sinisan (SNS) consists of four kinds of herbs, which is the core of
antidepressant prescription widely used in traditional Chinese medicine clinic treatment for …

Clinical depression is a multifactorial disorder and one of the leading causes of disability
worldwide. The alterations in tryptophan metabolism such as changes in the levels of …

Mitochondria maintain the normal physiological function of nerve cells by producing
sufficient cellular energy and performing crucial roles in maintaining the metabolic balance …

Objective Patients with hypertension have a risk of depression. Morinda officinalis
oligosaccharides (MOOs) have anti-depressant properties. In this study, we aimed to …