Recent findings of mitochondrial abnormalities in brains from subjects with neurological
disorders have led to a renewed search for mitochondrial abnormalities in psychiatric …

Gene expression changes in neuropsychiatric and neurodegenerative disorders, and gene
responses to therapeutic drugs, provide new ways to identify central nervous system (CNS) …

BACKGROUND: Hippocampal dentate granule neurons are altered in schizophrenia, but it
is unknown if their gene expressions change in schizophrenia or other psychiatric diseases …

The growth in popularity of RNA expression microarrays has been accompanied by
concerns about the reliability of the data especially when comparing between different …

There are to date no objective clinical laboratory blood tests for mood disorders. The current
reliance on patient self-report of symptom severity and on the clinicians' impression is a rate …

Given the mounting convergent evidence implicating many more genes in complex
disorders such as bipolar disorder than the small number identified unambiguously by the …

BACKGROUND: Schizophrenia and bipolar disorder together affect approximately 2.5% of
the world population, and their etiologies are thought to involve multiple genetic variants and …

Mitochondrial defects in gene expression have been implicated in the pathophysiology of
bipolar disorder and schizophrenia. We have now contrasted control brains with low pH …

Women are under-represented in research on suicidality to date. Although women have a
lower rate of suicide completion than men, due in part to the less-violent methods used, they …

Gene expression profiles of postmortem brain tissue represent important resources for
understanding neuropsychiatric illnesses. The impact (s) of quality covariables on the …