The complex link between the female genital microbiota, genital infections, and inflammation

S Dabee, JAS Passmore, R Heffron… - Infection and …, 2021 - Am Soc Microbiol
The female genital tract microbiota is part of a complex ecosystem influenced by several
physiological, genetic, and behavioral factors. It is uniquely linked to a woman's mucosal …

Gardnerella Revisited: Species Heterogeneity, Virulence Factors, Mucosal Immune Responses, and Contributions to Bacterial Vaginosis

E Shvartsman, JE Hill, P Sandstrom… - Infection and …, 2023 - Am Soc Microbiol
Gardnerella species are associated with bacterial vaginosis (BV) and have been
investigated as etiological agents of the condition. Nonetheless, the isolation of this taxon …

IgA coating of vaginal bacteria is reduced in the setting of bacterial vaginosis (BV) and preferentially targets BV-associated species

K Murphy, M Gromisch, S Srinivasan, T Wang… - Infection and …, 2024 - Am Soc Microbiol
Immunoglobulin (Ig) bacterial coating has been described in the gastrointestinal tract and
linked to inflammatory bowel disease; however, little is known about Ig coating of vaginal …

Lacticaseibacillus rhamnosus Lcr35 stimulates epithelial vaginal defenses upon Gardnerella vaginalis infection

S Miquel, J Verlaguet, S Garcin, T Bertran… - Infection and …, 2022 - Am Soc Microbiol
Dysbiosis of the vaginal microbiome as a result of overgrowth of anaerobic bacteria, such as
Gardnerella vaginalis, and low levels of “healthy” lactobacilli leads to bacterial vaginosis …

Commensal lactobacilli metabolically contribute to cervical epithelial homeostasis in a species-specific manner

NR Jimenez, JD Maarsingh, P Łaniewski… - MSphere, 2023 - Am Soc Microbiol
In reproductive-age women, the vaginal microbiome is typically dominated by one or a few
Lactobacillus species, including Lactobacillus crispatus, Lactobacillus iners, Lactobacillus …

Increased genital mucosal cytokines in Canadian women associates with increased antigen presenting cells, inflammatory metabolites, epithelial barrier disruption …

CF Zuend, A Lamont, L Noel-Romas, S Knodel, K Birse… - 2022 - researchsquare.com
Background: Cervicovaginal inflammation has been linked to negative reproductive health
outcomes including acquisition of HIV, other sexually transmitted infections, and cervical …