Ethnobotany and the role of plant natural products in antibiotic drug discovery

G Porras, F Chassagne, JT Lyles, L Marquez… - Chemical …, 2020 - ACS Publications
The crisis of antibiotic resistance necessitates creative and innovative approaches, from
chemical identification and analysis to the assessment of bioactivity. Plant natural products …

Rhodomyrtus tomentosa (Aiton.): A review of phytochemistry, pharmacology and industrial applications research progress

Z Zhao, L Wu, J Xie, Y Feng, J Tian, X He, B Li, L Wang… - Food chemistry, 2020 - Elsevier
Rhodomyrtus tomentosa (Aiton) is a flowering plant native to southern and southeastern
Asia. Up to date, 106 chemical constituents have been isolated and identified from R …

Brønsted Acid Catalyzed, Conjugate Addition of β‐Dicarbonyls to In Situ Generated ortho‐Quinone Methides—Enantioselective Synthesis of 4‐Aryl‐4H‐Chromenes

O El‐Sepelgy, S Haseloff, SK Alamsetti… - Angewandte Chemie …, 2014 - Wiley Online Library
We describe herein a catalytic, enantioselective process for the synthesis of 4H‐chromenes
which are important structural elements of many natural products and biologically active …

Asymmetric total synthesis of polycyclic xanthenes and discovery of a WalK activator active against MRSA

MJ Cheng, YY Wu, H Zeng, TH Zhang, YX Hu… - Nature …, 2024 - nature.com
The development of new antibiotics continues to pose challenges, particularly considering
the growing threat of multidrug-resistant Staphylococcus aureus. Structurally diverse natural …

Investigation of in vitro and in vivo antioxidant activities of flavonoids rich extract from the berries of Rhodomyrtus tomentosa (Ait.) Hassk

P Wu, G Ma, N Li, Q Deng, Y Yin, R Huang - Food chemistry, 2015 - Elsevier
This study investigated the in vitro and in vivo antioxidant activities of the flavonoids rich
extract from Rhodomyrtus tomentosa Hassk (R. tomentosa) berries. The in vitro antioxidant …

Rhodomyrtone: A new candidate as natural antibacterial drug from Rhodomyrtus tomentosa

S Limsuwan, EN Trip, TRHM Kouwen, S Piersma… - Phytomedicine, 2009 - Elsevier
Rhodomyrtone [6, 8-dihydroxy-2, 2, 4, 4-tetramethyl-7-(3-methyl-1-oxobutyl)-9-(2-
methylpropyl)-4, 9-dihydro-1H-xanthene-1, 3 (2H)-di-one] from Rhodomyrtus tomentosa …

Attenuation of quorum sensing system and virulence in Vibrio cholerae by phytomolecules

S Saha, S Aggarwal, DV Singh - Frontiers in Microbiology, 2023 - frontiersin.org
The Vibrio cholerae, a gram-negative bacterium, is the causative agent of cholera. Quorum
sensing is a cell-to-cell communication that leads to gene expression, accumulation of …

Antioxidant capacity of anthocyanins from Rhodomyrtus tomentosa (Ait.) and identification of the major anthocyanins

C Cui, S Zhang, L You, J Ren, W Luo, W Chen, M Zhao - Food Chemistry, 2013 - Elsevier
The anthocyanins in the fruits of Rhodomyrtus tomentosa (ACN) were extracted by 1% TFA
in methanol, and then purified by X-5 resin column and C18 (SPE) cartridges. The purified …

Iminium–Allenamine Cascade Catalysis: One‐Pot Access to Chiral 4H‐Chromenes by a Highly Enantioselective Michael–Michael Sequence

X Zhang, S Zhang, W Wang - Angewandte Chemie International Edition, 2010 - infona.pl
Taking the Michael‐Michael: A cascade Michael–Michael reaction of aryl or alkyl alkynals,
involving an unprecedented iminium–allenamine sequence, is efficiently catalyzed by a …

Inhibition of staphyloxanthin biosynthesis in Staphylococcus aureus by rhodomyrtone, a novel antibiotic candidate

S Leejae, L Hasap… - Journal of medical …, 2013 - microbiologyresearch.org
Staphyloxanthin is the eponymous feature of the human pathogen Staphylococcus aureus,
and the pigment promotes resistance to reactive oxygen species and host neutrophil-based …