In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

Ferroptosis is a form of regulated cell death that is characterized by iron-dependent
oxidative damage and subsequent plasma membrane ruptures and the release of damage …

200 billion red blood cells (RBCs) are produced every day, requiring more than 2× 10 15
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …

Immunometabolism explores how the intracellular metabolic pathways in immune cells can
regulate their function under different micro-environmental and (patho-)-physiological …

Iron is a vital trace element for humans, as it plays a crucial role in oxygen transport,
oxidative metabolism, cellular proliferation, and many catalytic reactions. To be beneficial …

Iron accumulation is a key mediator of several cytotoxic mechanisms leading to the
impairment of redox homeostasis and cellular death. Iron overload is often associated with …

Iron fulfils a central role in many essential biochemical processes in human physiology; thus,
proper processing of iron is crucial. Although iron metabolism is subject to relatively strict …

Iron is vital for almost all organisms because of its ability to donate and accept electrons with
relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen …

Iron is essential for many biological functions and iron deficiency and overload have major
health implications. We performed a meta-analysis of three genome-wide association …

Abstract α-Enolase 1 (ENO1) is a critical glycolytic enzyme whose aberrant expression
drives the pathogenesis of various cancers. ENO1 has been indicated as having additional …