Tuberculosis (TB) remains one of the most widespread and leading deadliest diseases,
threats one-third of the world's population. Although numerous efforts have been undertaken …

The practice of polypharmacology is not a new concept but the approaches which are being
adopted for administering the two or more drugs together are varied from time to time …

Piperazine is one of the most sought heterocyclics for the development of new drug
candidates. This ring can be traced in a number of well established, commercially available …

Tuberculosis, a disease of poverty is a communicable infection with a reasonably high
mortality rate worldwide. 10 Million new cases of TB were reported with approx 1.4 million …

Abstract Twelve novel 1H-1, 2, 3-triazole-tethered gatifloxacin (GTFX) isatin conjugates 5a-l
with greater lipophilicity compared with GTFX were designed, synthesized and evaluated for …

Piperazine, is privileged six membered nitrogen containing heterocyclic ring also known as
1, 4-Diazacyclohexane. Consequently, piperazine is a versatile medicinally important …

Hybridization, a strategy based on the covalent fusion of two or more existing
pharmacophores to create a single molecule with multiple mechanisms of action, represents …

A series of thirty eight novel 3-(4-((substituted-1H-1, 2, 3-triazol-4-yl) methyl) piperazin-1-
yl/1, 4-diazepan-1-yl) benzo [d] isoxazole and 1-(4-(benzo [d] isoxazol-3-yl) piperazin-1-yl/1 …

ABSTRACT Twenty-eight novel 1, 2, 3-triazole analogues of imidazo-[1, 2-a]-pyridine-3-
carboxamide were designed and synthesized based on hybridization approach. The …

A series of thirty one novel 2-(((1-(substituted phenyl)-1H-1, 2, 3-triazol-4-yl) methoxy)
carbonyl)-3-methylquinoxaline-1, 4-dioxide (7a-l), 3-(((1-(substituted phenyl)-1H-1, 2, 3 …