Roflumilast alleviates adenine-induced chronic kidney disease by regulating inflammatory biomarkers
The present investigation was carried out to explore the role of roflumilast, a PDE4 inhibitor,
as a potential treatment option for chronic kidney disease. Forty-six male Wistar rats were …
as a potential treatment option for chronic kidney disease. Forty-six male Wistar rats were …
Green Synthesis of Zinc Oxide-Nanoparticles from Ziziphus Spina-Christi Leaves Extract: Characterization and Their Protective Effects Against Liver Disturbances in …
Abstract Zinc oxide nanoparticles (ZnO-NPs) have a significant feature due to their uses in
various fields including medicine, biosensors, food additives, and electronic materials. This …
various fields including medicine, biosensors, food additives, and electronic materials. This …
Hepato-toxic risk of gum arabic during adenine-induced renal toxicity prevention
Objective: Lately, gum arabic (GA) is traditionally used in Middle East countries to ameliorate
renal function of patients with chronic renal failure (CRF). This action is controversial and it is …
renal function of patients with chronic renal failure (CRF). This action is controversial and it is …
[HTML][HTML] Synergistic impacts of rifampicin and doxorubicin against thioacetamide-induced hepatocellular carcinoma in rats
ZR Elshahawy, EA Saad, RR El-Sadda - Liver Research, 2023 - Elsevier
Background and aims Combination therapy is a promising new strategy that has been
proposed to increase the efficacy of cancer treatment. We aimed to investigate the anti …
proposed to increase the efficacy of cancer treatment. We aimed to investigate the anti …
A newly synthesized derivative and a natural parent molecule: Which would be more beneficial as a future antitumor candidate? Docking and in vivo study
EA Saad, F Zahran, FZ El-Ablack… - Applied Biochemistry and …, 2022 - Springer
Seeking for new effectual anticancer drugs is of great importance. In this study, a newly
synthesized and well-characterized chromene derivative (ethyl 2-amino-4-phenyl-4H-benzo …
synthesized and well-characterized chromene derivative (ethyl 2-amino-4-phenyl-4H-benzo …
Single-nucleotide polymorphisms (SNPs) of antioxidant enzymes SOD2 and GSTP1 genes and SLE risk and severity in an Egyptian pediatric population
Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease
associated with increased oxidative stress that participates in immune dysregulation, and …
associated with increased oxidative stress that participates in immune dysregulation, and …
Loading of some quinoxaline derivatives in poly (l-lactic) acid/Pluronic® F-127 nanofibers enhances their anticancer efficiency and induces a p53 and p21 apoptotic …
The objective of this study was to evaluate the anticancer activity on cancer cell models of a
drug delivery system consisting of poly (l-lactic) acid/Pluronic® F-127 (PLLA/PF127) loaded …
drug delivery system consisting of poly (l-lactic) acid/Pluronic® F-127 (PLLA/PF127) loaded …
The new iron (III) 3‐oxo‐N‐(pyridin‐2‐yl) butanamide complex promotes Ehrlich solid tumor regression in mice via induction of apoptosis
Currently used chemotherapeutic drugs had serious adverse effects eg myelo‐suppression,
anemia and nephrotoxicity. Thus, developing new alternatives is of great importance. We …
anemia and nephrotoxicity. Thus, developing new alternatives is of great importance. We …
Rifampicin efficacy against doxorubicin-induced cardiotoxicity in mice
Background The toxic effect of doxorubicin on the heart limits its clinical usage in cancer
therapy. This work intended to investigate, for the first time, the efficacy of rifampicin …
therapy. This work intended to investigate, for the first time, the efficacy of rifampicin …
Synthesis, characterization, and antitumor activity of a new iron-rifampicin complex: a novel prospective antitumor drug
Rifampicin is a semi-synthetic derivative of rifamycin. It has a broad antibacterial activity. Iron
is the most plentiful transition metal in human body. It is a crucial nutrient needed for …
is the most plentiful transition metal in human body. It is a crucial nutrient needed for …