Research Review: How to interpret associations between polygenic scores, environmental risks, and phenotypes

JB Pingault, AG Allegrini, T Odigie… - Journal of Child …, 2022 - Wiley Online Library
Background Genetic influences are ubiquitous as virtually all phenotypes and most
exposures typically classified as environmental have been found to be heritable. A …

Ethical, legal, and social implications of genetic risk prediction for multifactorial disease: a narrative review identifying concerns about interpretation and use of …

CR Chapman - Journal of Community Genetics, 2023 - Springer
Advances in genomics have enabled the development of polygenic scores (PGS),
sometimes called polygenic risk scores, in the context of multifactorial diseases and …

Genomic basis of high-altitude adaptation in Tibetan Prunus fruit trees

X Wang, S Liu, H Zuo, W Zheng, S Zhang, Y Huang… - Current Biology, 2021 - cell.com
Summary The Great Himalayan Mountains and their foothills are believed to be the place of
origin and development of many plant species. The genetic basis of adaptation to high …

Can adult polygenic scores improve prediction of body mass index in childhood?

K Lange, JA Kerr, T Mansell, JM O'Sullivan… - International Journal of …, 2022 - nature.com
Background/objectives Modelling genetic pre-disposition may identify children at risk of
obesity. However, most polygenic scores (PGSs) have been derived in adults, and lack …

Perspective on beyond statistical significance: finding meaningful effects

HJ Edenberg - Complex Psychiatry, 2021 - karger.com
Genome-wide association studies (GWASs) in psychiatry have recently identified many loci
that affect a wide variety of disorders and related traits, although the number of associated …

Ethical, Legal and Social Implications of Polygenic Scores for Multifactorial Disease: A Narrative Review Identifying Concerns About Interpretation and Use

CR Chapman - 2022 - researchsquare.com
Advances in genomics have enabled the development of polygenic scores (PGS),
sometimes called polygenic risk scores, in the context of multifactorial traits and diseases …