miRNAs as cornerstones in colorectal cancer pathogenesis and resistance to therapy: A spotlight on signaling pathways interplay—A review

MA Elrebehy, S Al-Saeed, S Gamal, A El-Sayed… - International journal of …, 2022 - Elsevier
Colorectal cancer (CRC) is the world's third most prevalent cancer and the main cause of
cancer-related mortality. A lot of work has been put into improving CRC patients' clinical …

Circulating microRNA biomarker studies: pitfalls and potential solutions

KW Witwer - Clinical chemistry, 2015 - academic.oup.com
BACKGROUND Circulating microRNAs have been proposed as disease biomarkers that
may aid in risk assessment, diagnosis, prognosis, and monitoring of treatment response …

Circulating miRNAs: roles in cancer diagnosis, prognosis and therapy

G Cheng - Advanced drug delivery reviews, 2015 - Elsevier
MicroRNAs (miRNAs) belong to a class of small non-coding RNAs that regulate numerous
biological processes by targeting a broad set of messenger RNAs. Recently, miRNAs have …

New concepts in cancer biomarkers: circulating miRNAs in liquid biopsies

E Larrea, C Sole, L Manterola, I Goicoechea… - International journal of …, 2016 - mdpi.com
The effective and efficient management of cancer patients relies upon early diagnosis and/or
the monitoring of treatment, something that is often difficult to achieve using standard tissue …

Programmable Analysis of MicroRNAs by Thermus thermophilus Argonaute-Assisted Exponential Isothermal Amplification for Multiplex Detection (TEAM)

Q Lin, G Han, X Fang, H Chen, W Weng… - Analytical …, 2022 - ACS Publications
The simultaneous analysis of the levels of multiple microRNAs (miRNAs) is critical to the
early diagnosis of cancer. However, this analysis is challenging because of the low …

Dissecting miRNA signature in colorectal cancer progression and metastasis

X Huang, X Zhu, Y Yu, W Zhu, L Jin, X Zhang, S Li… - Cancer letters, 2021 - Elsevier
Colorectal cancer (CRC) is the third most common cancer and leading cause of cancer
related deaths worldwide. Despite recent advancements in surgical and molecular targeted …

MicroRNAs in the etiology of colorectal cancer: pathways and clinical implications

AM Strubberg, BB Madison - Disease models & …, 2017 - journals.biologists.com
MicroRNAs (miRNAs) are small single-stranded RNAs that repress mRNA translation and
trigger mRNA degradation. Of the∼ 1900 miRNA-encoding genes present in the human …

Blood-based microRNAs as biomarkers for the diagnosis of colorectal cancer: a systematic review and meta-analysis

JV Carter, NJ Galbraith, D Yang, JF Burton… - British journal of …, 2017 - nature.com
Background: Colorectal cancer (CRC) is common and associated with significant mortality.
Current screening methods for CRC lack patient compliance. microRNAs (miRNAs) …

miR-19a promotes colorectal cancer proliferation and migration by targeting TIA1

Y Liu, R Liu, F Yang, R Cheng, X Chen, S Cui, Y Gu… - Molecular cancer, 2017 - Springer
Background Colorectal cancer (CRC) is a major worldwide health problem due to its high
prevalence and mortality rate. T-cell intracellular antigen 1 (TIA1) is an important tumor …

DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer

Y Toiyama, Y Okugawa, A Goel - Biochemical and biophysical research …, 2014 - Elsevier
Cancer initiation and progression is controlled by both genetic and epigenetic events.
Epigenetics refers to the study of mechanisms that alter gene expression without …